نتایج جستجو برای: forced swimming test fst

تعداد نتایج: 867679  

Journal: :avicenna journal of phytomedicine 0
bahareh amin department of pharmacology and physiology, school of medicine, sabzevar university of medical sciences, sabzevar, iran alireza nakhsaz pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad iran hossein hosseinzadeh pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective: the present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of crocus sativus l. (saffron) using mice in two different regimens of acute and sub-acute administration. material and methods: in acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 1999
R Andreatini L F Bacellar

The present study evaluated the correlation between the behavior of mice in the forced swimming test (FST) and in the elevated plus-maze (PM). The effect of the order of the experiments, i.e., the influence of the first test (FST or PM) on mouse behavior in the second test (PM or FST, respectively) was compared to handled animals (HAND). The execution of FST one week before the plus-maze (FST-P...

2006
Caroline Morini Calil Fábio José Bianchi Ana Paula Tanno Tatiana de Sousa da Cunha Fernanda Klein Marcondes C. M. Calil F. J. Bianchi A. P. Tanno T. S. Cunha F. K. Marcondes

Analysis of the meaning of the immobility time in swimming experimental models The aim of this work was to evaluate if the meaning of immobility (helplessness or adaptation) depends on the experimental model (forced swimming test or swimming stress). Immobility time (IT) and glycogen mobilization of rats submitted to swimming session were analyzed in two protocols: swimming stress (SS) and forc...

Journal: :The journal of medical investigation : JMI 2005
Hiroyuki Sakakibara Kaori Ishida Yuki Izawa Yuko Minami Satomi Saito Yoshichika Kawai Veronika Butterweck Toshiaki Tamaki Yutaka Nakaya Junji Terao

Chronic stress has been reported to be an essential factor for depression. In this study, the effect of forced swimming stress on neurotransmitters and cellular signaling pathway contributing to brain functions was investigated using the forced swimming test (FST) in order to understanding of mechanisms to regulate stress signals in brain. Antidepressant drug, imipramine, significantly reduced ...

Journal: :avicenna journal of phytomedicine 0
zahra shahamat depatment of pharmacology, pharmaceutical sciences branch, islamic azad university, tehran, iran. saeid abbasi-maleki department of pharmacology, urmia branch, islamic azad university urmia, iran saeid mohammadi motamed department of pharmacognosy, pharmaceutical science branch, islamic azad university, tehran, iran

objective: pimpinella anisum (p. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. in this study the antidepressant-like effect of aqueous and ethanolic extracts of p. anisum fruit in mice was investigated. materials and methods: forced swimming test (fst) and tail suspension test (tst) were used to determi...

Journal: :Journal of Neuroscience Methods 2011
T. J. Mezadri G. M. Batista A. C. Portes J. Marino-Neto C. Lino-de-Oliveira

The forced swim test (FST) is a pre-clinical test to short and long term treatment with antidepressant drugs (ADT), which requires between-subject designs. Herein a modified protocol of the FST using within-subject design (repeated rat-FST) was evaluated. Male Wistar rats were submitted to 15 min of swimming (Day 1: pretest) followed by three subsequent 5 min-swimming tests one week apart (Day ...

Journal: :avicenna journal of phytomedicine 0
ghulam moinuddin department of pharmacology, al-ameen college of pharmacy, near lalbagh main gate, bangalore-560027. india kshama devi department of pharmacology, al-ameen college of pharmacy, near lalbagh main gate, bangalore-560027. india deepak kumar khajuria department of pharmacology, al-ameen college of pharmacy, near lalbagh main gate, bangalore-560027. india

objective: the present study was undertaken to evaluate anti-depressant activity of myristica fragrans(ms). materials and methods: male wistar rats were subjected to imipramine and herbal extract ofms for their antidepressant activity using forced swimming test (fst), reserpine reversal test (rrt), haloperidol-induced catalepsy (hic), and pentobarbitone sleeping time (pst). results: administrat...

Journal: :Asian Journal of Pharmaceutical and Clinical Research 2023

Objectives: The aim of the study is to evaluate antidepressant activity ethanolic extract leaves Moringa oleifera L. (EEMO) on albino mice. Methods: anti-depressant was evaluated using forced swimming test (FST) and tail suspension (TST). Healthy mice were individually swim inside a vertical glass cylinder. Climbing, swimming, immobility tested recorded. In TST, suspended string held by metal s...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
L G Kirby I Lucki

We used in vivo microdialysis to examine extracellular levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum and the lateral septum during the forced swimming test, (FST) a behavioral test conducted in rats that is commonly used to predict the effect of antidepressant drugs. The forced swimming test consisted of a 15-min pretest swim and a 5-min test swim ...

Journal: :Acta cirurgica brasileira 2008
Honório Sampaio Menezes Bárbara Beatriz Moreira Bueno Leandro Ciulla Alexandre Schuh Fernanda de Freitas Luz Rafael José Vargas Alves Milena Pacheco Abegg Sílvia Letícia Merceo Bacchi Cirino

PURPOSE To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS Rats given injectio...

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