moclobemide is a selective and reversible monoamine oxidase-a inhibitor, which is used as an antidepressant. three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. so, n-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1h-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...

objective(s): in this study the effect of crocin, a carotenoid isolated from saffron, on malathion (an organophosphate insecticide) induced depressive- like behavior in subacute exposure was investigated. moreover the molecular mechanism of malathion induced depressive- like behavior and its decreasing effect on the level of brain derived neurotrophic factor (bdnf) in rat hippocampus and cerebr...

background: physical exercise is known to be a stressor stimulus that leads to reproductive disruption.objective: the aim of this study was to evaluate the effect of forced swimming on the uterus and ovaries in mice.materials and methods: adult mice (n=24) were divided into the following threegroups: a, control; b, swimming in water (10popc); and c, swimming in water (23popc).swimmers swam for ...

Background To determine brain areas involved in the antidepressant-related behavioral effects of the selective neuronal nitric oxide synthase inhibitor 1-(2-Trifluoro-methyl-phenyl) imidazole (TRIM) and experimental test compound 4-((3,5-dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid (ZL006), an inhibitor of the PSD of 95 kDa/neuronal nitric oxide synthase interaction in the N-methyl-D-a...

background physical activity and alteration of temperature as a source of stress may have adverse effects on male reproduction. objectives the aim of this study was to investigate the effect of chronic swimming and standing in cold, warm and lukewarm water on mouse spermatogenesis. materials and methods forty-nine male mice (n = 49) were randomly divided into seven groups: c, control; swc, swim...

in this study, the effects of siraitia grosvenorii fruits extracts (sgfe) on physical fatigue were investigated. one hundred and forty-four mice were randomly divided into four groups: control group, low-dose sge-treated group, middle-dose sge-treated group and high-dose sgfe-treated group. the animals of control group received an oral administration of physiological saline in a volume of 2.5 m...

Endogenous opioid regulation of neurohypophysial and hypothalamo-pituitary-adrenal (HPA) axis hormone secretion in response to forced swimming (90 s in deep water at 19 degrees C) was investigated in virgin and 21-day-pregnant rats. There was no difference in basal plasma oxytocin concentrations between pregnant and virgin rats, but the opioid antagonist, naloxone, increased basal oxytocin secr...

Depression occurs frequently in patients with diabetes mellitus. Chromium picolinate, an essential trace element is recommended for diabetes and also has been reported to benefit depression, but its mechanism is still debated. To investigate the mechanism, we studied its effects on serum insulin, serum glucose and on modified forced swimming test, a behavioural paradigm for depression in rats. ...