background and aim: steroid-resistant nephrotic syndrome (srns) accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. these patients are at risk of developing end-stage renal disease. the aim of this study was to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and prognosis in pediatric patients with srns.materials and met...

background: primary focal segmental glomerulosclerosis (fsgs) is defined by the presence of proteinuria, often in nephrotic range and pathologically by segmental scars (ss). the aim of this study is to identify the possible predictors of complete remission or progression to chronic kidney disease in iranian adults with primary focal segmental glomerulosclerosis. methods: in this historical coho...

      Schimke immune-osseous dysplasia (SIOD) is a rare autosomal recessive disorder presented with specific facial features, skeletal dysplasia, steroid resistance nephrotic syndrome (SRNS) and cellular immune insufficiency. This is a SIOD case reported from Iran. He was 5 years old boy when evaluated for proteinuria and short stature. In appearance, we detected hyperpigmented macules, kyphosc...

Focal segmental glomerulosclerosis is a form of chronic kidney disease that causes 3.6% of end stage renal disease cases. While the cause of this disease is multifactoral, the Human Genome Project has identified some specific chromosome sites linked to this disease process. Treatment for focal segmental glomerulosclerosis may include corticosteroids, managing hypertension, and controlling prote...

Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness to immunosuppressive therapy and a risk of recurrence after kidney transplant-important disease characteristics. In contrast, adaptive FSGS is associated with excessive nephron workload due to increased body size, reduced nephron ...

Idiopathic focal segmental glomerulosclerosis (FSGS) is a primary glomerular disease that essentially represents a form of chronic, progressive renal fibrosis for which there is no discernible cause. Often presenting with or eventually manifesting the nephrotic syndrome, this disease is increasing in incidence in both children and adults. Therapy continues to be a challenge, although some patie...