keloids are aesthetically disfiguring and severely disabling. the optimal treatment remains undefined. this clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-fluorouracil on the prevention of keloids. in this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. the control group were treated by periles...

In this work, the electronic properties of BP and CSi Nano cones have been investigated by self-consistent reaction field (SCRF) method in water solvent at B3PW91/6-31G (d,p) level of DFT theory for study of  for interactions of 5-Fluorouracil Anticancer Drug with theses Nano cones. The percent of change of energy gap (%ΔEg) shows that the complex formation of 5-Fluorouracil with BP ...

5-fluorouracil is a widely used anticancer drug with many side effects on humans, and hence its analysis in biological samples is very important. Accordingly, a novel sensitive electrochemical approach was fabricated by incorporating graphene quantum dots (GCD) and 1-butylpyridinium bromide (BPBr) in the formulation of a carbon paste electrode (GQD/BPBr/CPE). The GQD was synthesized and charact...

Introduction: Drugs are mainly delivered to the target tissues by plasma proteins, such as human serum albumin, in the human body. Practical information about the thermodynamic parameters of drugs and their stability can be obtained using simulation methods, such as molecular docking. Material & Methods: This study, investigated the molecular docking of human serum albumin with fluorouracil an...

density functional theory (dft) calculations were performed to investigate the effects of a carbon nanotube (cnt) on the properties of the fluorouracil (f-uracil) anticancer drug. to achieve the purpose, a molecular model including both of f-uracil and cnt molecules was created to represent the cnt@f-uracil compound. the optimized parameters indicated that the new compound could show new proper...

In this study, a simple strategy was described for the synthesis of Pt-SWCNTs conductive nanocomposite by microwave heated polyol method and nanocomposite characterized by EDS, FESEM, and XRD method. The Pt nanoparticles were decorated at the surface of SWCNTs with a diameter of 22.3 nm. The synthesized nanocomposite was used for modification of the carbon paste electrode (CPE) in the presence ...

Abstract Background The skin is both a target and potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated superparamagnetic iron oxide nanoparticles to facilitate transdermal anticancer agents. Results Chemotherapeutic cancer drugs were applied with or without hairless mice, their ability penetrate was assessed usi...

Fluorouracil has been in clinical use as an anticancer drug for 30 years. Although this drug has a broad spectrum of anticancer activity, including significant activity against the common solid tumors of the gastrointestinal system, only a minority of patients treated with fluorouracil experience an objective response to therapy. Furthermore, in randomized clinical trials completed to date, it ...

Background: The tumor vascular microenvironment has an important role in progression and metastasis. objective of this study was to assess the significance metastatic hepatic relation response systemic fluorouracil-based chemotherapy [folinic acid/fluorouracil/oxaliplatin (FOLFOX) or folinic acid/fluorouracil/irinotecan (FOLFIRI)]. Patients Methods: A total 48 consecutive patients with colorect...

We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a small dose-dependent anti-proliferative effect, with an IC50 of 90 microM. In...