The unique properties of fluorine atom on nucleic acid backbone can offer stricking functional and structural features. In order to extend the biological applications L-type acid, we chemically incorporate fluoro-modification into 2′-position L-cytidine, obtain a series fluoro-modified L-DNAs/ L-RNAs. Our melting study indicates that 2′-fluoro-modification does not disrupt thermostabilities wil...

Reaction of thionyl chloride with 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid 1 gave acid chloride 2. Compound 2 was reacted with glycine and D-glutamic acid to afford 2-(7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4- dihydroquinoline-3-carbonyl) aminopantandioicacid 3a and 2-(7-chloro-1-cyclopropyl-6- fluoro -4- oxo-1,4-dihydroquinoline-3-carbonyl)aminoacetica...

A series of derivatives (E)-6-chloro-5-fluoro-2-styryl-1H-benzo[d]imidazole, and 5-fluoro-2-methylN-phenyl-1H-benzo[d]imidazol-6-amine was synthesized. Compounds confirmed by melting point, FT-IR, 1HNMR, Mass spectral analytical techniques predicted for their ADME, Pharmacokinetic properties.Synthesized compounds screened better antibacterial antiinflammatory activity. To synthesize a novel tri...

traffic accident has increased in the last decade. one of the most important outcomes of accident is spinal cord injury (sci). so, cell therapy is obtained a greater attention in most fields of medicine because of its potential for incurable diseases through replacing of dead cells. the current study aims to describe the important of locomotor functional and structural connection of the spinal ...

General: [S:2] Representative procedures: [S:3] Characterization data: 6-fluoro-6-phenyl-hexanoic acid (1): [S:4, S:10-S:12] methyl 6-fluoro-6-phenylhexanoate (2): [S:4, S:13-S:15] 6-fluoro-6-phenylhexan-1-ol (3): [S:4, S:16-S:18] 6-fluoro-6-(p-tolyl)hexanoic acid (4): [S:5, S:19-S:21] 6-(4-(tert-butyl)phenyl)-6-fluorohexanoic acid (5): [S:5, S:22-S:24] 6-fluoro-6-(4-fluoro)phenyl-hexanoic acid...

In previous work, we demonstrated that 4-fluoroproline residues can contribute greatly to the conformational stability of the collagen triple helix, and that this stability arises from stereoelectronic effects that fix the pucker of the pyrrolidine ring and thereby preorganize the backbone properly for triple-helix formation. Here, we take a reciprocal approach, demonstrating that the steric ef...

The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline get 2-amino-6-fluoro-7-chloro (1,3) benzothiazole (I), this was treated with anilino-s-methyl ethylene cyanoacetamide in the presence of ethanol desired molecules. synthesized targeted molecules are characterized, docked and screened for their invitro ...

Mục tiêu: Xây dựng quy trình định lượng chấtcần sa tổng hợp 5-FLUORO-MDMB-PICA có trong mẫu ma túy thu thập được bằng phương pháp sắc ký khí ghép đầu dò khối phổ (GC-MS). Đối tượng và pháp: Mẫu cần chứa các dạng cỏ Mỹ vụ án tại Việt Nam từ năm 2018 đến 2020, xử lý dùng làm thử để thẩm GC-MS theo hướng dẫn của ICH. Kết quả: Quy phân tích,định 5-FLUORO-MDMB-PICA, đã xác điều kiện thích pic tách h...