objective(s) the present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. materials and methods antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. results promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhi...

background and objective: considering the wide side effects of synthetic pain killers, use of herbal drugs in folk medicine as analgesic agents has increased. in the present work, we tried to uncover the pharmacological potential of ethanolic extracts by using various animal models and also to explore the potent antinociceptive effect of the plant thymus kotschyanus. materials and methods: the ...

AIM To study the effects of somatostatin (SST) and its antagonist cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr [Bzl]) (SSA) on morphine-induced analgesia. METHODS The pain assays were the hot plate and the tail flick test. RESULTS SST or SSA per se administered intracerebrally at the doses of 0.1 and 1 mg/mouse did not change the pain threshold of mice both in the hot plate and in the tail fli...

objective(s): the aim of study was to investigate the antinociceptive effect of intracerebroventricular (icv) microinjection of origanum vulgare (org) extract and possible involvement of opioid receptors.   materials and methods: cannula was inserted into left ventricle of male rats. five days after surgery tail flick latency (tfl) was measured after icv microinjection of, org (1, 3 and 6 μg / ...

introduction: the antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. one of the major components of this pathway is the nucleus raphe magnus (nrm). our previous study demonstrated the involvement of nrm in the analgesic effect of morphine microinjected into the nucleus cuneiformis (ncf) in a descending manner. the aim of the current study wa...

objective(s) current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of teucrium chamaedrys in mice and rats. materials and methods for evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. results the extract of t. c...

Unilateral deafferentation induced by transection of the C(4)-C(8) dorsal roots of spinal cord, followed by a complex of abnormal self-mutilating behavior, is interpreted as an animal model of chronic nociception. The objective of our study was to test the differences in tail-flick latency between intact control and unilaterally deafferented animals and to assess the changes in their acute noci...

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was com...

The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin and abdominal constriction tests were the most sensitive procedures for the detection of hyperalg...