OBJECTIVE This non-systematic review discusses the available evidence on the use of flavoxate in the treatment of overactive bladder (OAB). METHODS Medline was searched for inclusion of relevant studies. No limitations in time were considered. RESULTS Flavoxate hydrochloride is an antispasmodic agent which exerts an inhibition of the phosphodiesterases, a moderate calcium antagonistic activ...

The effects of clenbuterol, a selective beta 2-agonist, on isolated smooth muscle preparations from the rabbit bladder body, bladder base and proximal urethra have been investigated. The inhibitory effects on resting tension and acetylcholine- and field stimulation-induced contractions in the bladder body were compared with those of flavoxate, atropine, and verapamil. Clenbuterol (10(-10)-10(-7...

Abstract The utility of carbon paste electrode for the determination of flavoxate HCl modified with flavoxate-tetraphenylborate (FLX-TPB) and flavoxate-phosphotungestic acid (FLX-PTA) ion-pairs in batch mode is demonstrated. The electrodes revealed a Nernstian response over a wide concentration ranges 1.39×10-5-1x10-2 mol L-1 and1×10-5-1x10-2 mol L-1 using FLX-TPB and FLX-PTA, respectively. The...

OBJECTIVES To provide an overview on the efficacy, tolerability, safety and health-related quality of life (HRQoL) of drugs with a mixed action used in the treatment of overactive bladder (OAB). EVIDENCE ACQUISITION MEDLINE database and abstract books of the major conferences were searched for relevant publications from 1966 to 2011 and using the key words 'overactive bladder', 'detrusor over...

The objective of this study was to develop simple, precise, accurate and sensitive UV spectrophotometric methods for the simultaneous determination of ofloxacin (OFX) and flavoxate HCl (FLX) in pharmaceutical formulations. The first method is based on absorption ratio method, by formation of Q absorbance equation at 289 nm (λmax of OFX) and 322.4 nm (isoabsorptive point). The linearity range wa...

abstract the utility of carbon paste electrode for the determination of flavoxate hcl modified with flavoxate-tetraphenylborate (flx-tpb) and flavoxate-phosphotungestic acid (flx-pta) ion-pairs in batch mode is demonstrated. the electrodes revealed a nernstian response over a wide concentration ranges 1.39×10-5-1x10-2 mol l-1 and1×10-5-1x10-2 mol l-1 using flx-tpb and flx-pta, respectively. the...

Nitrofurantoin has been used commonly as an antimicrobial treatment for urinary tract infections. Although the combination of lung and liver cytotoxicity is very rare, it may occur up on treatment with nitrofurantoin. Nitrofurantoinassociated pulmonary interactions are common among females. The anticholinergic and antimuscarinic effects of Flavoxate hydrochloride enhance the selective relaxant ...

The objective of the study was to develop a high performance liquid chromatography (HPLC) method using ultra violet (UV) detection for the determination of flavoxate HCl in bulk and solid dosage forms by using ibuprofen as the internal standard. Eclipse C18 column (150 mm × 4.6 mm, 5 μm) was used as the stationary phase with a mixture of acetonitrile : 0.1% formic acid in water (75: 25 v/v) as ...