introduction: although formalin-induced activity in primary afferent fibers and spinal dorsal ‎horn is well described, the midbrain neural basis underlying each phase of behavior in ‎formalin test has not been clarified. the present study was designed to investigate the nucleus ‎cuneiformis (cnf)‎‏ ‏neuronal responses during two phases after subcutaneous injection of ‎formalin into the hind paw...

Introduction: Loss of inhibitory output from Purkinje cells leads to hyperexcitability of the Deep Cerebellar Nuclei (DCN), which results in cerebellar ataxia. Also, inhibition of small-conductancecalcium-activated potassium (SK) channel increases firing rate  f DCN, which could cause cerebellar ataxia. Therefore, SK channel activators can be effective in reducing the symptoms of this disease, ...

objective: it is well known that intracerebroventricular (icv) and supraspinal injections of orexin-a elicit analgesia, but the mechanism(s) of action remains unidentified. this study aims to characterize the effect of orexin-a on rostral ventromedial medulla (rvm) neurons which are involved in the descending nociception modulating pathway. materials and methods: in this experimental study, we ...

introduction: loss of inhibitory output from purkinje cells leads to hyperexcitability of the deep cerebellar nuclei (dcn), which results in cerebellar ataxia. also, inhibition of small-conductancecalcium-activated potassium (sk) channel increases firing rate  f dcn, which could cause cerebellar ataxia. therefore, sk channel activators can be effective in reducing the symptoms of this disease, ...

We review a recent approach to the mean-field limits in neural networks that takes into account the stochastic nature of input current and the uncertainty in synaptic coupling. This approach was proved to be a rigorous limit of the network equations in a general setting, and we express here the results in a more customary and simpler framework. We propose a heuristic argument to derive these eq...

Neuronal activity is measured by the number of stereotyped action potentials, called spikes, elicited in response to a stimulus or the behavioral conditions of an animal. Any nonparametric method for grasping the time-varying rate of spike firing contains a single parameter that controls the jaggedness of the estimated rate, such as the binsize of the time histogram or the bandwidth of the kern...