abstract breast cancer is a multifactorial disease. benign breast disease (bbd) is one of the most important risk factors for breast cancer. the etiology of bbd is unknown. it is divided into nonproliferative and proliferative diseases. the selection of studies will be based on titles, abstract screening, inclusion and exclusion criteria, and quality assessment. previous studies have shown that...

Increases in risk of breast cancer in successive generations of migrants to the United States from China and rapid temporal changes in incidence rates in China following social and economic changes clearly implicate environmental factors in the etiology of this disease. Case-control and cohort studies have provided evidence that at least some of these factors may be dietary. Iron, an essential ...

background: increasing serum levels of uric acid (sua) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate sua. estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. the study aimed to explore sua among patients suffering from these diseases to enhance the hypothesis. methods: overall , 1349 female participants we...

Background: Fibrocystic disease of the breast in one of the commonest diseases in women above 30 years of age. The assumption of it being innocuous and benign is questionable with increased incidence of malignancies developing in these women. Introduction: Understanding the pathophysiology of fibrocystic disease is essential for identifying determinants of malignant change. Case Report: A case ...

The association between cigarette smoking and the occurrence of benign breast disease was assessed in a hospital-based case-control study conducted in Connecticut during 1979-81. Current smokers, but not former smokers, were at reduced risk for all benign breast diseases. The odds ratios associated with current smoking were 0.7 (95% confidence intervals = 0.6, 0.9) for fibrocystic breast diseas...

Introduction. Fibrocystic disease of the male breast is uncommon. The presence of a spectrum of changes ranging from fibrocystic disease to duct papilloma to papillary carcinoma in the same patient renders the case a rarity and therefore reportable. Case Report. A case of intracystic papillary carcinoma of the male breast is presented. Discussion. The pathological, clinical, diagnostic, and the...

OBJECTIVE Inhibins and activins are members of the transforming growth factor beta superfamily and are known to modulate the growth and differentiation of several cell types. The present study investigated the localization of inhibin and activin subunits in human normal and pathological breast tissues. DESIGN A cross-sectional study comparing the expression of inhibin/activin subunits alpha, ...

Abstract Objectives The objectives of this study are to review fibrocystic changes of the breast, their causal and associated factors and their correlation to mastalgia, and then to review the available treatment options for mastalgia (caused by fibrocystic changes) short of surgery. Methods The author reviews all the articles obtained from a PubMed research on mastalgia and fibrocystic changes...

Common variants in genes encoding for key enzymes involved in steroidogenesis may alter sex steroid hormone levels, thereby influencing susceptibility to breast carcinoma and related conditions. In a case-control study of Chinese women, we examined genotypes of the CYP11A1 pentanucleotide [(TAAAA)n] repeat (D15S520), CYP17A1 rs743572, and HSD17B1 rs605059 polymorphisms in relation to the risk o...