Complement factor H (FH) and factor-H-like protein 1 (FHL-1) are human plasma proteins with regulatory functions in the alternative pathway of complement activation. FH and FHL-1 are organized in repetitive elements termed short consensus repeats (SCRs) and the seven SCRs of FHL-1 are identical with the N-terminal domain of the 20 SCRs of FH. The fourth SCR of both proteins (SCR 4) includes the...

Recently, the Factorized Hidden Layer (FHL) adaptation is proposed for speaker adaptation of deep neural network (DNN) based acoustic models. In addition to the standard affine transformation, an FHL contains a speaker-dependent (SD) transformation matrix using a linear combination of rank-1 matrices and an SD bias using a linear combination of vectors. In this work, we extend the FHL based ada...

OBJECTIVE In the functional screening of a human heart cDNA library to identify a novel antiangiogenic factor, the prime candidate gene was "four-and-a-half LIM only protein-2" (FHL-2). The goal of this study is to clear the mechanism of antiangiogenic signaling of FHL-2 in endothelial cells (ECs). METHODS AND RESULTS Overexpressed FHL-2 strongly inhibited vascular endothelial growth factor (...

BACKGROUND Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of infancy or early childhood. To clarify the incidence and subtypes of FHL in Japan, we performed genetic and functional analyses of cytotoxic T lymphocytes (CTLs) in Japanese patients with FHL. DESIGN AND METHODS Among the Japanese children with hemophagocytic lymphohistiocytosis (HLH) registered at our laborator...

Abstract Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder which less typical in adults than pediatric patients. In this study, we reported rare case of adult-onset FHL3 with progressive lymphocytosis and lymphocytic interstitial pneumonia (LIP). A 20-year old female was admitted to our institution for persistent cough fever. chest high-resolution compute...

Familial hemophagocytic lymphohistiocytosis (FHL) is caused by genetic defects in cytotoxic granule components or their fusion machinery, leading to impaired natural killer cell and/or T lymphocyte degranulation and/or cytotoxicity. This may accumulate into a life-threatening condition known as macrophage activation syndrome. STXBP2, also known as MUNC18-2, has recently been identified as the d...

During mixed-acid fermentation Escherichia coli produces formate, which is initially excreted out the cell. Accumulation of formate, and dropping extracellular pH, leads to biosynthesis of the formate hydrogenlyase (FHL) complex. FHL consists of membrane and soluble domains anchored within the inner membrane. The soluble domain comprises a [NiFe] hydrogenase and a formate dehydrogenase that lin...

The fermentation product of herbs by lactic acid bacteria (FHL) was assayed for antifungal activities against Rosellinia necatrix, Helicobasidium mompa, Fusarium oxysporum, Pythium graminicola and Pyricularia oryzae. FHL completely inhibited the growth of R. necatrix, H. mompa, P. graminicola and P. oryzae, and reduced the growth of F. oxysporum by 35%. When the seeds of Medicago sativa L. (alf...

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, genetically heterogeneous autosomal recessive immune disorder that results when the critical regulatory pathways that mediate immune defense mechanisms and the natural termination of immune/inflammatory responses are disrupted or overwhelmed. To advance the understanding of FHL, we performed gene expression profiling of peripheral blo...

Functional health literacy (FHL) involves skills in writing, reading, oral expression, comprehension, and numerical calculations to successfully function complete health-related tasks. This study aimed develop validate an instrument for measuring FHL the Philippines using a mixed-method design. FHL-5TEST is consisting of five questions developed consultation with local experts, translated major...