Fibroblast growth factor receptor 2 (FGFR-2) contributes to the progression of numerous types of cancers; however, its role in glioma has yet to be determined. We investigated the expression of FGFR-2 and its predominant isoforms, FGFR-2 IIIb and FGFR-2 IIIc, in gliomas of all histological grades. Using immunohistochemistry, we demonstrated that FGFR-2, FGFR-2 IIIb and FGFR-2 IIIc were expresse...

This study examined the expression of fibroblast growth factor receptor 2 (FGFR 2) splice variants, IIIb and IIIc, in normal and malignant human oral keratinocytes and in normal oral fibroblasts by RT-PCR using both exon-specific primers and primers common to both FGFR 2 isoforms. Fibroblasts expressed exclusively FGFR 2/IIIc whilst the normal and malignant keratinocytes co-expressed FGFR 2/III...

Mutations in FGFR 1-3 genes account for various human craniosynostosis syndromes, while dwarfism syndromes have been ascribed exclusively to FGFR 3 mutations. However, the exact role of FGFR 1-3 genes in human skeletal development is not understood. Here we describe the expression pattern of FGFR 1-3 genes during human embryonic and fetal endochondral and membranous ossification. In the limb bu...

PURPOSE To map the expression and distribution of FGFR and potential FGFR-related signaling molecules within rat and human retina. METHODS Sections of postnatal 5 day old and adult rat, and aged human retina, and cell cultures prepared from selected cell populations of young rat retina, were immunolabeled with specific antisera to FGFR (FGFR-1, -2, -3, and -4) or candidate signaling molecules...

FGFR–TACC, found in different tumor types, is characterized by the fusion of a member fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks FGFR–TACC fusions are present many hematological disorders and there no data on prevalence, we studied series patients with acute myeloid l...

Signals mediated by fibroblast growth factor (FGF) family members are transduced into target cells by tyrosine kinase transmembrane receptors (FGFRs). The FGFR family includes four distinct receptors, FGFR-1, −2, −3 and -4 which share a common general structure. The extracellular domain contains three immunoglobulin-like domains. The first and the second domains are separated by a stretch of ac...

PURPOSE Extensive correlative studies in human prostate cancer as well as studies in vitro and in mouse models indicate that fibroblast growth factor receptor (FGFR) signaling plays an important role in prostate cancer progression. In this study, we used a probe compound for an FGFR inhibitor, which potently inhibits FGFR-1-3 and significantly inhibits FGFR-4. The purpose of this study is to de...

Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified. Therefore, we decided to examine the expression of both FGFR-2 isoform, FGFR-2-IIIb and FGFR-2-IIIc, in different histological thyroid variants such as hyperplasia, follicular adenoma and...

Соматические активирующие изменения генов FGFR1-4 выявляются в 5-10% всех опухолей человека. Применение новых селективных FGFR-ингибиторов позволяет улучшить результаты лечения местно-распространённого и метастатического уротелиального рака холангиокарциномы с активирующими изменениями генах FGFR2 FGFR3. В рамках клинических испытаний изучаются возможности применения препаратов из этого класса ...

Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic efficacy. We performed a transcriptome analysis to characterize the response of various cancer cell li...