Two prominent alpha-fetoproteins are found in chick embryo plasma up to and slightly beyond hatching. Only antisera against chick embryo plasma resolve them. alpha3-fetoprotein is a lipoprotein, the first fetoprotein thus described. It probably functions to transport lipid from the yolk to the embryo. The other fetoprotein (alpha4) is a major glycoprotein. Both are made by the liver and yolk sa...

Posterior midline cervical cystic hygromas (PMC) are frequently found associated with chromosomal aberrations and usually do not survive. The present report illustrates diagnosis of this condition by sonography in an 18 weeks old fetus and an amniocentesis revealed 45 x0 karyotype and increased concentration of alpha-fetoproteins. Pregnancy was terminated in view of Turner's syndrome. The etiol...

aim of this study is to determine the risk of adverse pregnancy outcome by maternal serum alpha-fetoprotein (msafp) level. we followed 295 pregnant women from msafp screening in the 14th to 22th week of gestation until the end of pregnancy and information on pregnancy outcome have been recorded in questionnaires. of 295 pregnant women, 270 had term labor and 25 had preterm labor. the frequencie...

Fetal fluid was studied in mice of the Q, C57BL/McL, C3H/Bi/McL and JU/Fa strains. The amount increases to day 16 of gestation, and then decreases. Amniotic fluid and fetal plasma contain three transferrins, five alpha-fetoproteins and albumin. Protein concentration in both increases during gestation; glucose decreases in amniotic fluid although it rises in fetal plasms; urea levels remain cons...

conclusions the data from this cohort indicates that most of patients diagnosed with hcc present at late tumor and liver disease stages, when prognosis is usually dismal. regular cancer surveillance in cirrhotic patients might change the outcomes. further studies with results of treatment outcomes in this community are needed. background hepatocellular carcinoma (hcc) is one of the leading caus...

Hepatic tumours are relatively rare in children, accounting for 1% 4% of all paediatric solid tumors, commonest amongst them are hepatoblastoma, neuroblastoma, and vascular tumors (hemangioendothelioma/haemangiomas). Infantile Hepatic hemangioendothelioma (IHHE) is classically characterised by hepatomegaly, jaundice, congestive cardiac failure with high cardiac output, skin haemangiomas, haemol...

Background: Mid-trimester maternal serum markers have been used for prenatal aneuploidy screening a long time. The aim of the study was to assess mid-term levels β-human chorionic gonadotropin and alpha-fetoproteins placenta-mediated adverse pregnancy outcomes (PMAPOs) in preterm term pregnancies.
 Material methods: A prospective cohort involving nulliparous women with singletons without o...

We have explored immobilized metal affinity chromatography as a means of resolving alpha-fetoprotein from its homologous albumin, a problem perennially encountered in the purification of an alpha-fetoprotein or its detection. Human alpha-fetoprotein and human serum albumin were chromatographed on immobilized iminodiacetic acid charged with either Co2+, Ni2+, Cu2+, or Zn2+. Neither human alpha-f...