conclusions vitamin c supplementations after 14th weeks of gestation can prevent from pprom in women with the history of pprom. results pprom occurred in 44.7% of controls and 31.8% of cases (p < 0.05). prom occurred in 34.1% of controls and 18.8% of cases (p < 0.05). pregnancy was terminated at term gestation in 21.2% of controls and 49.4% of cases (p < 0.05). rupture of membranes was signific...

introduction: preterm birth is still a major health problem throughout the world, which results in 75% of neonatal mortality. preterm labor not only inflicts financial and emotional distress, it may also lead to permanent disability. the present study was conducted to determine the related risk factors and preventive measures of preterm labor. methods: this retrospective cross-sectional study a...

background: morbidity and mortality of preterm babies are important issues in perinatal medicine. in developed countries, preterm delivery is the cause of about 70% of mortality and 75% of morbidity in the neonatal period, respectively. objective: the aim of this study was to determine the risk factors for preterm labor and the outcomes, in terms of perinatal mortality and morbidity at the time...

The general outcome of these six experimental cases and those already reported is that both motile and non-motile types produce disease of the fetal membranes eventually leading to abortion. The more precise serological relations between the two are now under investigation.

The fetal membranes fulfill several functions during pregnancy. In addition to containing the products of conception and amniotic fluid, they presumably have barrier functions and fulfill paracrine signaling functions between the maternal (decidual) and fetal compartments. As the membranes are in an ideal place to receive both maternal and fetal signals and transmit signals to uterine myometriu...

The clinical application of the fetal membranes dates back to nearly a century. Their use has ranged from superficial skin dressings to surgical wound closure. The applications of the fetal membranes are constantly evolving, and key to this is the uncovering of multiple populations of stem and stem-like cells, each with unique properties that can be exploited for regenerative medicine. In addit...

OBJECTIVE To assess the predictive value of quantitative fetal fibronectin (fFN) concentration in cervicovaginal fluid for spontaneous preterm birth in women with bulging fetal membranes. STUDY DESIGN This was a prospective observational study from five UK tertiary centres of a cohort of women with singleton pregnancy and bulging fetal membranes presenting between 18 and 32 weeks of gestation...

BACKGROUND Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition. The aim of this study was to determine the effect of supracervical apposition and spontaneous labour on apoptosis and MMP-9 in human fetal membranes at term. METHODS Fe...