نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

Journal: :iranian journal of biotechnology 2006
alireza zebarjadi

the biosynthetic pathways of saturated and unsaturated fatty acids consist of many steps controlled by various enzymes. one of the methods for improving oil quality is to change the fatty acid profile through genetic manipulation which requires isolation and characterization of the genes and other cis-acting elements, such as the promoter, involved in fatty acid biosynthesis. b-ketoacyl-coa syn...

The biosynthetic pathways of saturated and unsaturated fatty acids consist of many steps controlled by various enzymes. One of the methods for improving oil quality is to change the fatty acid profile through genetic manipulation which requires isolation and characterization of the genes and other cis-acting elements, such as the promoter, involved in fatty acid biosynthesis. b-ketoacyl-CoA syn...

2010
Maria Tikhonenko Todd A. Lydic Yun Wang Weiqin Chen Madalina Opreanu Andrew Sochacki Kelly M. McSorley Rebecca L. Renis Timothy Kern Donald B. Jump Gavin E. Reid Julia V. Busik

OBJECTIVE The results of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort study revealed a strong association between dyslipidemia and the development of diabetic retinopathy. However, there are no experimental data on retinal fatty acid metabolism in diabetes. This study determined retinal-specific fatty acid metabolism in control and...

Journal: :Journal of lipid research 2002
Takashi Matsuzaka Hitoshi Shimano Naoya Yahagi Tomohiro Yoshikawa Michiyo Amemiya-Kudo Alyssa H Hasty Hiroaki Okazaki Yoshiaki Tamura Yoko Iizuka Ken Ohashi Jun-Ichi Osuga Akimitsu Takahashi Shigeru Yato Hirohito Sone Shun Ishibashi Nobuhiro Yamada

The mammalian enzyme involved in the final elongation of de novo fatty acid biosynthesis following the building of fatty acids to 16 carbons by fatty acid synthase has yet to be identified. In the process of searching for genes activated by sterol regulatory element-binding protein 1 (SREBP-1) by using DNA microarray, we identified and characterized a murine cDNA clone that is highly similar to...

2011
Xiaozhong Zheng Douglas R. Tocher Cathryn A. Dickson Alan J. Teale

Running title: HUFA gene expression in salmon fed vegetable oil Abstract Fish are an important dietary source of the long-chain C 20 and C 22 highly unsaturated fatty acids (HUFA), arachidonate (20:4n-6), eicosapentaenoate (20:5n-3) and docosahexaenoate (22:6n-3), that are crucial to the health of higher vertebrates and that can be beneficial in human diets. Δ5 and Δ6 fatty acid desaturases, an...

2003
Morris Agaba Douglas R. Tocher Cathryn A. Dickson James R. Dick Alan J. Teale

Running title: Multifunctional fatty acid elongase of zebrafish Summary: Enzymes that increase the chain length of fatty acids are essential for biosynthesis of highly unsaturated fatty acids. The gLELO gene encodes a protein involved in the elongation of polyunsaturated fatty acids in the fungus Mortierella alpina. A search of the Genbank database identified several EST sequences, including on...

2014
Mulan Jiang Bing Guo Xia Wan Yangmin Gong Yinbo Zhang Chuanjiong Hu

The diatom Phaeodactylum tricornutum can accumulate eicosapentaenoic acid (EPA) up to 30% of the total fatty acids. This species has been targeted for isolating gene encoding desaturases and elongases for long-chain polyunsaturated fatty acid (LC-PUFA) metabolic engineering. Here we first report the cloning and characterization of Δ5-elongase gene in P. tricornutum. A full-length cDNA sequence,...

2011
Katsutoshi Tsuda Takafumi Akiba Fumiko Kimura Mayu Ishibashi Chihiro Moriya Kiyotaka Nakagawa Nori Kurata Yukihiro Ito

Organisms are covered extracellularly with cuticular waxes that consist of various fatty acids. In higher plants, extracellular waxes act as indispensable barriers to protect the plants from physical and biological stresses such as drought and pathogen attacks. However, the effect of fatty acid composition on plant development under normal growth conditions is not well understood. Here we show ...

2017
Meng Zhang Cui-Cui Li Fang Li Hong Li Xiao-Jun Liu Juan J. Loor Xiang-Tao Kang Gui-Rong Sun

The very long chain fatty acid elongase (ELOVL) plays an important role in the synthesis of long-chain polyunsaturated fatty acids (LCPUFA). Previous studies suggest that chicken could be an alternate source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study, we detected that ELOVL5, which plays a key role in the biosynthesis of omega-3 (n-3) and omega-6 (n-6) polyunsa...

2013
Jordi Corominas Yuliaxis Ramayo-Caldas Anna Puig-Oliveras Dafne Pérez-Montarelo Jose L. Noguera Josep M. Folch Maria Ballester

BACKGROUND The ELOVL fatty acid elongase 6 (ELOVL6), the only elongase related to de novo lipogenesis, catalyzes the rate-limiting step in the elongation cycle by controlling the fatty acid balance in mammals. It is located on pig chromosome 8 (SSC8) in a region where a QTL affecting palmitic, and palmitoleic acid composition was previously detected, using an Iberian x Landrace intercross. The ...

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