Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is ...

We use the Rosetta de novo structure prediction method to produce three-dimensional structure models for all Pfam-A sequence families with average length under 150 residues and no link to any protein of known structure. To estimate the reliability of the predictions, the method was calibrated on 131 proteins of known structure. For approximately 60% of the proteins one of the top five models wa...

Recently we proposed a novel method of alignment-alignment comparison, COMPASS (the tool for COmparison of Multiple Protein Alignments with Assessment of Statistical Significance). Here we present several examples of the relations between PFAM protein families that were detected by COMPASS and that lead to the predictions of presently unresolved protein structures. We discuss relatively straigh...

Recent welfare reform legislation requires increased parental work effort and imposes time limits on the receipt of federal assistance. These changes were based in part on assumptions that parental welfare receipt may be negatively related to family processes and children's attitudes and behaviors. Currently, researchers know little about the effects of welfare by itself relative to the effects...

In August 1996, Congress and the president replaced the 60-year-old Aid to Families with Dependent Children (AFDC) program with a block grant, Temporary Assistance to Needy Families (TANF), permitting states to experiment with new forms of assistance to low-income families. States seem likely to try increasingly ambitious reforms as they gain experience under their TANF flexibility, at least if...

background: accidents, such as domestic accidents, and the resulting injuries are presently a matter of concern in communities. some factors such as urbanization cause an increase in the incidence of accidents for recognized and unrecognized reasons. the aim of the present study was to investigate the incidence of domestic accidents among a group of families who had migrated to the determined u...

available on-line contains supplemental material with the sequences of the unigenes predicted from P. infestans and a comparison of the frequencies of Pfam domains in predicted proteins from P. infestans, Neurospora crassa, and Arabidopsis thaliana. e-Xtra*