background : acute myeloid leukemia (aml) is a disease in elderly patients, with a mean age of diagnosis of 70 years. we have analyzed the clinicopathology features and experimental variables in aml patients in eastern iran and the correlation between survival and fab subgroups of aml. materials and methods : during 2009 to 2014 in a retrospective study, 98 patients with aml referred to the cli...

introduction: about half of acute myeloid leukemia (aml) adult patients have no cytogenetic abnormalities as a main determinant of complete remission after treatment, so other markers are needed such as flt3-itd (fms-like tyrosine kinase3-internal tandem duplication) mutations in patients with normal karyotype. the objective of this study was assessing the frequency of flt3-itd mutations and it...

The FAB classification of acute leukemias was proposed by a cooperative French-American-British group as an easily applied classification useful for uniform assessment of large clinical therapeutic trials. Although the classification is based on morphological criteria, cytochemical, biochemical, immunological and cytogenetic studies supplement the morphologic criteria for accurate identificatio...

BACKGROUND In March 1997 an international workshop introduced a new International Prognostic Scoring System (IPSS) for MDS. The goal of the present study was to apply the IPSS to a large group of MDS patients from one centre and to compare it to the FAB-classification. PATIENTS One hundred eighty-four MDS patients were included on the basis of similar criteria as used by the workshop but some...

PURPOSE French-American-British (FAB) classification of acute leukemia with genetic heterogeneity is important for treatment and prognosis. However, the distinct protein profiles that contribute to the subtypes and facilitate molecular definition of acute leukemia classification are still unclear. EXPERIMENTAL DESIGN The proteins of leukemic cells from 61 cases of acute leukemia characterized...

BACKGROUND Assessment of frontal lobe impairment in amyotrophic lateral sclerosis (ALS) is a matter of great importance, since it often causes ALS patients to decrease medication and nursing compliance, thus shortening their survival time. METHODS The frontal assessment battery (FAB) is a short and rapid method for assessing frontal executive functions. We investigated the applicability of th...

This issue of Cancer Control focuses on the clinicopathologic features of chronic T-cell leukemia/ lymphoma. Chronic leukemia of T-cell origin was first identified by Brouet and colleagues in 1975. Several classification systems for T-cell lymphoid malignancies have been proposed since then. The French-American-British (FAB) Cooperative Group’s proposal for classification designated four subgro...

Acute myeloid leukemia (AML) has distinct subgroups characterized by different maturation and specific chromosomal translocation. In order to gain insight into the gene expression activities in AML, we carried out a gene expression profiling study with 21 AML samples using cDNA microarrays, focusing on acute promyelocytic leukemia with specific translocation t(15;17)(q22;q12) [French-American-B...

Classification The FAB and WHO classifications The French-American-British (FAB) cooperative group produced the first systematic attempt of a classification dividing myelodysplastic syndrome (MDS) into five subgroups: refractory anemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)1;2. Distin...

A group Γ is called boundedly generated (BG) if it is the settheoretic product of finitely many cyclic subgroups. We show that a BG group has only abelian by finite images in positive characteristic representations. We use this to reprove and generalise Rapinchuk’s theorem by showing that a BG group with the FAb property has only finitely many irreducible representations in any given dimension ...