there is strong evidence demonstrating that nifedipine dissolved in ethanol selectively inhibits only l-type ca2+ current. in addition, acute ethanol exposure reduces voltage-dependent calcium currents. in the present study, we investigated the antagonistic effect of fixed concentration of nifedipine dissolved in different concentration of ethanol on l-type ca2+ current. in a na+-k+ free soluti...

We present a physiologically plausible binaural mechanism for the perception of the pitch of complex sounds via ghost stochastic resonance. In this scheme, two neurons are driven by noise and a different periodic signal each (with frequencies f1 = kf0 and f2 = (k+1)f0, where k > 1), and their outputs (plus noise) are applied synaptically to a third neuron. Our numerical results, using the Morri...

A molecular description of the nerve terminal will be required to understand synaptic function fully. The goals of this study were to contribute toward such a description by characterizing a novel synapse-specific protein. A monoclonal antibody library was screened for antibodies to synaptic proteins. The antibodies were then used to isolate cDNA clones by expression screening. Here we report a...

introduction: the ionic currents show nonlinear behavior and electrical stimuli can influence their activation and inactivation kinetics. the time constant of depolarizing or hyperpolarizing current pulses has an important role in the firing behavior of neurons. in the present study, the effects of quasitrpezoidal command potentials on l-type calcium channel of somata of f1 neuron in helix aspe...

Larval motor neurons remodel during Drosophila neuro-muscular junction dismantling at metamorphosis. In this study, we describe the motor neuron retraction as opposed to degeneration based on the early disappearance of β-Spectrin and the continuing presence of Tubulin. By blocking cell dynamics with a dominant-negative form of Dynamin, we show that phagocytes have a key role in this process. Im...

genes that control motor neuron induction, subtype identity, and target specificity. Mice were mutagenized with ENU and outcrossed to an HB9-GFP transgenic reporter line that expresses GFP in spinal motor neurons and their axons. Litters were analyzed by fluorescence microscopy for recessive mutations that affect motor neuron induction and motor axon projection pattern. We have screened 137 F1 ...

genes that control motor neuron induction, subtype identity, and target specificity. Mice were mutagenized with ENU and outcrossed to an HB9-GFP transgenic reporter line that expresses GFP in spinal motor neurons and their axons. Litters were analyzed by fluorescence microscopy for recessive mutations that affect motor neuron induction and motor axon projection pattern. We have screened 137 F1 ...

genes that control motor neuron induction, subtype identity, and target specificity. Mice were mutagenized with ENU and outcrossed to an HB9-GFP transgenic reporter line that expresses GFP in spinal motor neurons and their axons. Litters were analyzed by fluorescence microscopy for recessive mutations that affect motor neuron induction and motor axon projection pattern. We have screened 137 F1 ...