background abnormalities of external genitalia in male children nurseries and inguinal hernia are the most common congenital disorders in children. we aimed to determine prevalence rate of inguinal hernia and other genital among children nurseries, in shahrood-iran. materials and methods in this descriptive cross-sectional study, we examined 920 children nurseries boys. physical examination of ...

Background: External genital anomalies are the most common congenital disorders in male infants with unknown etiology in the majority of cases. According to recent reports, incidence rate of these anomalies is rising in different countries. This study aimed to evaluate the prevalence of external genital anomalies and possible underlying factors in male newborns. Methods: This cross-sectional st...

background: external genital anomalies are the most common congenital disorders in male infants with unknown etiology in the majority of cases. according to recent reports, incidence rate of these anomalies is rising in different countries. this study aimed to evaluate the prevalence of external genital anomalies and possible underlying factors in male newborns. methods: this cross-sectional st...

Genital malformations occur at a high frequency in humans, affecting ~1:250 live births. The molecular mechanisms of external genital development are beginning to be identified; however, the origin of cells that give rise to external genitalia is unknown. Here we use cell lineage analysis to show that the genital tubercle, the precursor of the penis and clitoris, arises from two populations of ...

External genital development begins with formation of paired genital swellings, which develop into the genital tubercle. Proximodistal outgrowth and axial patterning of the genital tubercle are coordinated to give rise to the penis or clitoris. The genital tubercle consists of lateral plate mesoderm, surface ectoderm, and endodermal urethral epithelium derived from the urogenital sinus. We have...

In mammalian embryos, male and female external genitalia develop from the genital tubercle. Outgrowth of the genital tubercle is maintained by the urethral epithelium, and it has been reported that Fgf8 mediates this activity. To test directly whether Fgf8 is required for external genital development, we conditionally removed Fgf8 from the cloacal/urethral epithelium. Surprisingly, Fgf8 is not ...

Malformations of the external genitalia are among the most common congenital anomalies in humans. The urogenital and anorectal sinuses develop from the embryonic cloaca, and the penis and clitoris develop from the genital tubercle. Within the genital tubercle, the endodermally derived urethral epithelium functions as an organizer and expresses sonic hedgehog (Shh). Shh knockout mice lack extern...

Morphological description of sand,flies has remained a neglected area. The different organs used in taxonomy have not yet been described adequatelAy with the scanning electron microscopy (SEM). We have examined the external genital structures offemales of three Old World phlebotomine sand,flies under SEMand recorded the morphological variations of the organs. We have,found the,female external g...