a b s t r a c t there are three types of nerve fibers that are involved in the transmission of pain stimuli: c fibers (slower fibers) for thermal, mechanical and chemical stimuli, a-delta fibers for thermal or mechanical stimuli and a-beta fibers for touch stimuli. clinically, this is crucial in making an accurate assessment of the pain level experienced by a suffering patient, in indicating th...

INTRODUCTION Basal cell carcinoma (BCC) is the most common form of skin cancer; however, few data are available relating to patients' perspectives and experiences of this disease. This study explored the spectrum of BCC symptoms and their impact by disease stage to determine how BCC affects the overall health-related quality of life (HRQL) of patients. METHODS This study comprised a cross-sec...

We studied the effect of two social settings (collaborative versus competitive) on the visual and auditory expressions of uncertainty by children in two age groups (8 and 11). We conducted an experiment in which children played a quiz game in pairs. They either had to collaborate or compete with each other. We found that the Feeling-of-Knowing of eight-year-old children did not seem to be affec...

Quantum computers solve ever more complex tasks using steadily growing system sizes. Characterizing these quantum systems is vital, yet becoming increasingly challenging. The gold-standard state tomography (QST), capable of fully reconstructing a without prior knowledge. Measurement and classical computing costs, however, increase exponentially in the size - bottleneck given scale existing near...

BACKGROUND Child screen viewing (SV) is positively associated with poor health indicators. Interventions addressing rule-based parenting practices may offer an effective means of limiting SV. This study examined associations between rule-based parenting practices (limit and collaborative rule setting) and SV in 6-8-year old children. METHODS An online survey of 735 mothers in 2011 assessed: t...

Because many patients with unresectable basal cell carcinoma (BCC) are aged ≥65 years, this study explores the efficacy and safety of vismodegib in these patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC) in the ERIVANCE BCC trial and the expanded access study (EAS).We compared patients aged ≥65 years to patients aged <65 years taking vismodegib 150 mg/day, using d...