background: multiple sclerosis is a common and chronic neurologic disorder. this disorder imposes physical, economic, and psychosocial burden on individuals, their families and society. this study aims to analyze the costs of multiple sclerosis disease based on the severity of disability. methods: we performed a cross‑sectional cost of illness study. this study was conducted in 332 patients of ...

background: statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. objective: to evaluate the effects of atorvastatin in combination with interferon-β in the treatment of multiple sclerosis (ms) in a randomized controlled clinical trial. methods: multiple sclerosis patients were randomized independently, in a double b...

background: there is a known inverse association between solar radiation and the prevalence of multiple sclerosis (ms). some studies have investigated the link between vitamin d and ms. the aim of this study was to investigate the possible association between serum 25(oh) vitamin d3 concentration and the severity of disease in iranian patients with ms. methods: patients with relapsing-remitting...

background: multiple sclerosis (ms) is the most common disabling neurological disease. hand dysfunction is one of the main complaints of patients with ms. the present study aimed to compare hand dexterity of ms patients with low expanded disability status scale (edss) scores and healthy adults. it also sought to identify the predictors of disability status of patients with ms based on their man...

ramadan fasting predispose multiple sclerosis (ms) patients to a great challenge. clinicians should have practical knowledge about the effects of fasting on ms. a mini-symposium was held in 2013 to answer the common questions about fasting in ms patients. in current review we present a summary of the mentioned mini-symposium.generally, fasting is possible for most stable ms patients. thorough m...

conclusions the results suggested that apr1 gene expression in c. albicans strains isolated from ms patients may be an important factor for invasive c. albicans strains in the progression of ms disease. results there was a statistically significant difference in apr1 gene expression of c. albicans strains between ms patients (mean ± sd: 0.5208 ± 0.11518) and the control group (mean ± sd: 0.7603...

  Background: Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The present study aimed to compare hand dexterity of MS patients with low Expanded Disability Status Scale (EDSS) scores and healthy adults. It also sought to identify the predictors of disability status of patients with MS based on their m...

BACKGROUND The uncertainty about long-term effects of childbirth presents MS patients with dilemmas. METHODS Based on clinical data of 330 female MS patients, the long-term effects of childbirth were analysed, using a cross-sectional study design. Four groups of patients were distinguished: (1) without children (n = 80), (2) with children born before MS onset (n = 170), (3) with children born...

Previous studies have shown a preferential loss of grey matter in fronto-temporal regions in patients with multiple sclerosis. Studies of correlates of disease severity are more controversial, because some studies have suggested an association between sensorimotor cortex atrophy and Expanded Disability Status Scale score, while others did not find such a correlation. The objective of this study...

It is commonly recognized that proinflammatory cytokines in patients with multiple sclerosis (MS) may increasingly cause inflammation. In this regard, the current study was aimed to shed light on the effectiveness of eight-week Pilates training program at interleukin-18 (IL-18) stage, severity of fatigue and balance as well as physical disability in females with MS. This study was a quasi-exper...