More than 80% of patients treated with cetuximab develop an acneiform follicular skin exanthema. Grade 3 exanthema develops in 9-19% of these cases, bearing the risk of cetuximab dose-reduction or cessation. We retrospectively analysed a cohort of 20 patients treated with cetuximab and an in-house reactive skin protocol upon development of an exanthema. The reactive skin protocol was built up a...

Acute exanthema occurs in patients who are human immunodeficiency virus (HIV) positive before they become seropositive. The patients have influenza like symptoms and a macular skin rash on the upper trunk. Histopathological investigation of skin punch biopsy specimens from four patients with acute HIV exanthema showed a normal epidermis and a sparse dermal, mainly perivascular, lymphocytic/hist...

A 10-year-old Caucasian boy was referred for evaluation of an acute eruption that had developed over the past 8 days. The began in right popliteal fossa, and then coalesced spread along side his body. fever up to 38°C joint pain were reported 3 days before appearance skin lesions. Physical examination showed erythematous edematous macules papules on hemibody (Figure). left did not show any Labo...

We report on a 76-year-old male patient who developed a maculopapular generalised exanthema due to terbinafine. Prick test was negative; patch test revealed a positive reaction after 48 h confirming the delayed-type allergic reaction. Non-pustular exanthema has only rarely been reported for terbinafine.

DTH: delayed hypersensitivity IV: intravenous RCM: radio contrast media SDRIFE: systemic drug-related intertriginous and flexural exanthema INTRODUCTION Systemic drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous reaction, characterized by 5 diagnostic criteria (Table I). We report on 3 patients with SDRIFE induced by radio contrast media (RCM) and describe the dermatolo...

Febrile exanthema frequently presents as an acute condition in travelers. Sixty-two travelers who presented with febrile exanthema were prospectively included over a 20-month period. Diagnostic tests were performed according to clinical presentation and risk exposures. Symptoms occurred after return in 56% of these travelers, and the median interval between return and symptom onset was 2 days. ...

Main Characteristics of Zika Virus Exanthema in Guadeloupe Zika virus (ZIKV) has recently started to spread in the Americas leading to successive outbreaks from Brazil to the French West Indies.1 The virus was declared a public health emergency by theWorldHealthOrganization because of its unpredictable associated morbidity (eg, fatal outcomes and severe neurologic complications).1 However, the ...