Background: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) compartments, boosting tumor cell migration, invasion, and angiogenesis. Although Cripto-1 is ...

Oesophageal squamous carcinoma (ESCC) is one of the most lethal human malignancies worldwide, especially in China, due to its late-stage diagnosis, chemoradiotherapy resistance, and lack appropriate therapeutic targets corresponding formulations. In article number 2200251, Bing Jiang co-workers review latest genomics, diagnostics, etiology, researches ESCC provide a comprehensive discussion see...

objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...

introduction and aims: the role of human papillomavirus (hpv) in the etiology of esophageal squamous cell carcinoma (escc) is not clear. previous studies have found highly variable (from 0% to 67%) prevalence of hpv in escc tumor. however, prevalence of hpv in escc tumor seems to be higher in areas with high incidence of escc , such as china and south africa. iran is one of the areas of the wor...

Background: In view of the low accuracy prognosis model esophageal squamous cell carcinoma (ESCC), this study aimed to optimize least squares support vector machine (LSSVM) algorithm determine uncertain prognostic factors using a Cloud model, and consequently, establish new high-precision ESCC.

Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...

background:â  northeastern iran has a high incidence for squamous cell esophageal carcinoma (escc). the aim of the study is to the assess relationship between celiac disease (cd) and escc. materials and methods:â  this was a two-part, cross-sectional, case-control study performed during 2006-2011 in gonbad, â golestan, iran. serum iga anti-tissue transglutaminase antibody levels were measured f...

introduction: promoter methylation has an inhibitory effect on gene expression. thus we investigated methylation patterns of p15 gene in esophageal squamous cell carcinoma (escc), one of the most frequent and fetal cancers in the world. material and methods: p15 promoter methylation status of 30 escc and 10 normal specimens was investigated using methylation specific pcr. dna extracted from the...

Epidural spinal cord compression (ESCC) is a common metastatic complication occurring in 5% of patients with cancer. We sought to determine retrospectively the frequency of multiple sites of ESCC at presentation and the risk of recurrence of ESCC. Of the cancer patients seen by the University of California San Diego's Neuro-Oncology Service between August 1986 and January 1997, 108 developed ES...