Investigation on tritium was one of the recommendations in ERAB report of DOE in November, 1989. 15 year evolution of the related research proved that it was an important recommendation. A selective resonant tunneling model is attempted to explain this discovery. Deuterium flux might be a key issue to solve the problem of the reproducibility. A further investigation is suggested based on this m...

The alcohol dehydrogenase (ADH) activity of human short-chain l-3-hydroxyacyl-CoA dehydrogenase (SCHAD) has been characterized kinetically. The k(cat) of the purified enzyme was estimated to be 2. 2 min(-1), with apparent K(m) values of 280 mM and 22microM for 2-propanol and NAD(+), respectively. The k(cat) of the ADH activity was three orders of magnitude less than the l-3-hydroxyacyl-CoA dehy...

Cold fusion researchers consider the ERAB report highly prejudiced for many reasons. It was concluded in a rush long before there was time to perform and publish serious replications. The authors dismissed experimental evidence by pointing to theory, which is a violation of the scientific method. And they selectively ignored positive data. For example, ERAB report authors visited Dr. Melvin Mil...

of a paper to be present at the March 2004 meeting of American Physical Society. These abstracts can be seen at the APS web site: http://www.eps.org/aps/meet/MAR03/baps/abs/S9530.html 28) J.Bockris “Early Contributions From Workers at Texas A&M University to (So-Caled) Low Energy Nuclear Reactions.”Journal of New Energy, Vol 4, no 2, 1999, p. 40 29) J. Bockris, G. Lin, and N. Packham " A Review...

2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency is a novel inborn error of isoleucine degradation. In this article, we report the elucidation of the molecular basis of MHBD deficiency. To this end, we purified the enzyme from bovine liver. MALDI-TOF mass spectrometry analysis revealed that the purified protein was identical to bovine 3-hydroxyacyl-CoA dehydrogenase type II. The hu...

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Amplification and/or overexpression of the erhti-2 gene have been demonstrated in 20-30% of adenocarcinomas of the breast, ovary, lung, and stomach and are associated with aggressive clinical course and poor prognosis. Interference with erbB-2 function by the use of monoclonal antibodies is a promising approach to the treatment of these diseases. In this study we demonstrate that a combination ...

The characterization of scully, an essential gene of Drosophila with phenocritical phases at embryonic and pupal stages, shows its extensive homology with vertebrate type II L-3-hydroxyacyl-CoA dehydrogenase/ERAB. Genomic rescue demonstrates that four different lethal mutations are scu alleles, the molecular nature of which has been established. One of them, scu3127, generates a nonfunctional t...