human cytomegalovirus is one of the most common pathogenic viruses all over the world. in congenital infection leads to neurologic severe disorders and even death of fetus and in individuals with immunosuppression may also cause severe clinical symptoms. multiple evidence indicate that among several strategies, epitope-based vaccine (evs) that can induce both humoral and cellular immunity respo...

D m eferral for epicardial ablation frequently represents a “last itch” effort in uniquely difficult patients. Epicardial maping was the cornerstone that guided our early experience in he surgical ablation of arrhythmias (1). However, epicardial apping alone was insufficient to identify the site of origin of entricular tachycardias (VTs), particularly in patients with oronary artery disease and...

Background: Hepatitis C virus (HCV) causes acute and chronic human hepatitis infections. Due to the high genetic diversity and high rates of mutations in the genetic material so far there is no approved vaccine against HCV. Materials and Methods: The aim of this study was to determination B and T cell conserved epitopes of E1 and E2 proteins from HCV and construction of a chimeric pepti...

Consider the discrete 1D Schrödinger operator on Z with an odd 2k periodic potential q. For small potentials we show that the mapping: q → heights of vertical slits on the quasi-momentum domain (similar to the Marchenko-Ostrovski maping for the Hill operator) is a local isomorphism and the isospectral set consists of 2 distinct potentials. Finally, the asymptotics of the spectrum are determined...

background: there are two subclasses of human iga (iga1 and iga2) that differ in antigenic properties and in chemical composition. the constant domains of α1 and α2 heavy chains have >95% sequence homology though major structural differences exist in the hinge region. quantitation of iga subclass levels depends on the availability of monoclonal antibodies (mabs) specific for conserved conformat...

background hypervariability of hcv proteins is an important obstacle to design an efficient vaccine for hcv infection. multi-epitope vaccines containing conserved epitopes of the virus could be a promising approach for protection against hcv. objectives cellular and humoral immune responses against multi-epitope dna and peptide vaccines were evaluated in balb/c mice. materials and methods in th...

Abstract The purpose of this paper is to give a regularization variant of the inertial proximal point algorithm not only in an infinite-dimensional Banach space E, which is an uniformly smooth and uniformly convex, but also in its finite-dimensional approximations for finding a point in the nonempty intersection ∩i=1Ci, where N ≥ 1 is an integer and each Ci is assumed to be the fixed point set ...

brucellosis, produced by brucella species, is a disease that causes severe economic losses for livestock farms worldwide due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on brucella outer membrane protein (omp) antigens. in the present study, a wide range of on-line prediction sof...