epilepsy is one of the most common chronic disorders affecting individuals of all ages. a greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. therefore, several investiga...

  Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...

While statins were developed as drugs to suppress cholesterol synthesis, they also prevent vascular diseases off-target effects. Numerous experimental and clinical studies have proven that could be beneficial for reducing ictogenesis epileptogenesis. We aimed summarize elaborate on up-to-date evidence of the role in epilepsy consider mechanisms responsible their Key words: Statin; Epileptogenes...

Epileptogenesis is the process whereby a normal brain becomes epileptic. We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in the hippocampus during epileptogenesis and that BDNF-mediated activation of TrkB is required for epileptogenesis. We tested these hypotheses in Synapsin-Cre conditional BDNF(-/-) and TrkB(-/-) mice using the kind...

Abstract Background Epileptogenesis can be defined as the process by which a previously healthy brain develops tendency toward recurrent electrical activity, occurring in three phases: first an initial trigger (such stroke, infections, and traumatic injury); followed latency period onset of spontaneous seizures characterizes epilepsy. Main body The mechanisms that may involved epileptogenesis a...

Significance In numerous models of neurodevelopmental disorders and epilepsy, genetic mutations associated with enhanced mTORC1 activity engender an increase in the susceptibility to epileptic seizures. This study shows that deletion mTORC1-downstream translational repressor, 4E-BP2, but not 4E-BP1, promotes epileptogenesis. By deleting 4E-BP2 different cell types, we reveal up-regulation mTORC...

Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investiga...

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Genetic and pharmacological perturbations suggest that tyrosine receptor kinase B (trkB) receptor activation promotes limbic epileptogenesis, but whether or where trkB activation occurs during epileptogenesis is uncertain. Because activation of trk receptors involves phosphorylation of specific tyrosine residues (Segal et al., 1996), the availability of antibodies that selectively recognize the...