objective(s) considering fair response to inhaled corticosteroids and reports of severe air way hyper responsiveness in chemical warfare victims (cwv), a role for eosinophilic inflammation (i.e. asthma) was postulated. the objective of this study was to determine the presence of eosinophilic inflammation in cwv by evaluation of sputum cellularity and eosinophil cationic protein (ecp). materials...

purpose: in the present work, clinical symptoms, serum immunoglobuline alteration and eosinophil count were investigated in the patients infected with giardia lamblia. materials and methods: in this regard, 50 persons infected with giardia and 50 healthy individuals were selected as the study and control groups respectively in tehran. sera of the groups were tested for igg, ige, iga levels and...

the pathogenetic mechanism of nasal polyps remains unknown, although allergy has been cited as an important factor in the etiology of nasal polyposis. currently there is no definite histological criterion for differentiation of allergic from inflammatory nasal polyp. however, in a few studies, tissue eosinophil count has been used for this. this study aimed to find out the agreement rate of ski...

background: gnathostoma spinigerum causes larva migran in human which is endemic in southeast asia. information regarding larva migration is limited. in this study, we investigated the parasite migra­tion by recovery of worms from the whole body of mouse after oral infection with advanced third stage larvae (al3). the percentage of blood eosinophils was examined in parallel. methods: mice were ...

spirometry has been used as a common diagnostic test in asthma. most of the patients with a mild asthma have a fev1 within normal range. hence, other diagnostic methods are usually used. the aim of this study was to evaluate whether eosinophil cationic protein (ecp) could be an accurate diagnostic marker of mild asthma. in this study diagnosis of asthma was made according to internationally acc...

respiratory virus infection is a major cause of asthma exacerbation. however, the underlying mechanisms of  this exacerbation  are unknown. therefore,  to  determine  the mechanisms, we examined the effect of influenza infection in a murine model of asthma.mice were divided into four groups: the phosphate-buffered saline (pbs), house dust mite (hdm), influenza, and hdm/influenza groups. the inf...

Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor (TF) for eosinophil development, delineating the transcriptional networks that regulate eosinophil development at homeostasis and in inflammat...

Expression of the myeloid transcription factor GATA1 is required for early stages of eosinophil differentiation. Defining mechanisms regulating eosinophil GATA1 expression will be important to understand development of this lineage. However, the cis-elements required for eosinophil GATA1 expression are not fully characterized. Previous work identified HS 1 as a major GATA1 enhancer, but its rol...