spreading depression (sd), discovered by leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes. sd appears to act through several mechanisms and receptors which have not completely understood. here, we studied the effect of inhibitory system in animal model of sd using immunohistochemistry technique. after imp...

The effects of intraperitoneal injection of N6-cyclohexyladenosine (CHA, a selective adenosine A1 receptor agonist) and 8-cyclopenthyle-I-3-dimethylexanthine (CPT, a selective adenosine A1 receptor antagonist) on entorhinal cortex-kindled seizures were investigated. Fully entorhinal cortex-kindled rats received normal saline (control), CHA (0.06, 0.12 and 0.25 mg/kg) or CPT (0.06 and 0.12 mg/kg...

introduction: the role of adenosine a1 receptors of the entorhinal cortex on amygdaloid kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimulation of amygdala. in the full kindled animals, n6-cyclohexyladenosine (cha; 0.1, 1 and 10 mm), an adenosine a1 receptor agonist, and 8-cyclopenthyle 1,3-dimethylexanthine (cpt), an adenosine a1 receptor a...

introduction: the role of adenosine a1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimutation of entorhinal cortex. in the full kindled animals, n6-cyclohexyladenosine (cha 10, 50, 100, 500óm), an adenosine a1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (cpt, 10, 20 óm), an adeno...

introduction: in this study, the role of adenosine a1 receptors of hippocampal ca1 region neurons onentorhinal cortex kindled seizures was investigated. material and methods: a tripolar(stimulating and recording) electrode was implanted in entorhinalcortex and two guide cannulae were implanted in the ca1 region of the left and right hippocampi of allanimals. a week after surgery, animals were s...

The perirhinal and parahippocampal cortices constitute the major sources of cortical input to the monkey entorhinal cortex. Neuropsychological studies have shown that these three cortical regions contribute in an important way to normal memory function. We have investigated the topographic and laminar organization of the reciprocal projections between the entorhinal cortex and these two adjacen...