RAISED serum levels ofprotein-bound iodine (PBI) in patients with normal thyroid function have been observed on many occasions after oral treatment with 5-chloro-7-iodo-8-hydroxyquinoline (iodochlorhydroxyquinoline, clioquinol, Enterovioform) (Thoren, 1960; Levin, Josephson & Grtnewald, 1966; Sonksen et al., 1968). It is less well appreciated that clioquinol administered topically can be absorb...

In the course of a comprehensive survey of the chemotherapy of amcebiasis, Leake (1932) studied the properties of iodochlorhydroxyquinoline (enterovioform or vioform, N.N.R.) in comparison to chiniofon, N.N.R. (sodium iodohydroxyquinoline sulphonate) and certain other derivatives of hydroxyquinoline from the standpoint of oral toxicity in guinea-pigs and cats, amcebicidal action in vitro, and b...

the aim of this trial was to determine the toxic effect of oms-43 on spraymen and inhabitants. the spraying operation lasted for 30 successive days, and two teams consisting of 20 spraymen, 2 mixers, 4 foremen and team leaders were engaged in this operation. the operators were under systematic and closed clinical observation and cholinesterase determination (tintometric method) during the opera...