Enterotoxaemia, an economically important disease of sheep, goats and calves, is caused by systemic effects of the epsilon toxin produced by the anaerobic bacterium Clostridium perfringens type D. The only practical means of controlling the occurrence of enterotoxaemia is to immunise animals by vaccination. The vaccine is prepared by deriving a toxoid from the bacterial culture filtrate and the...

Aim: To compare the newly formulated enterotoxaemia vaccine having oil and alum adjuvants, with presently available toxoid and alum precipitated vaccines. Materials and Methods: Three types of enterotoxaemia vaccines, namely toxoid (TV), alum precipitated (APV) and alum precipitated oil adjuvant vaccine (AOV) were prepared using a highly toxigenic strain of Clostridium perfringens type D procur...

Antibody responses in sixty clinically healthy pregnant sheep and goats were compared following the administration of enterotoxaemia vaccine. The thirty animals of each species were randomly divided into three groups. Antibody titers against C. perfringens type D epsilon toxin were detected in blood samples on day 15, 30, 45, 60 and 75 post vaccination. In unvaccinated control groups, S-I (shee...

the present investigation was conducted to study the effects of experimental clostridium perfringens type d enterotoxaemia in teddy goats. clinical signs started to appear after 30 min of experimental infection like anorexia, diarrhea, dehydration, frothing and dyspnea. gross lesions consisted of severe congestion in tissues of varying intensity with enlarged mesenteric lymph nodes while histol...

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and haemorrhagic enteritis. The purpose of this study was to investigate the putative role of the more recently described beta2 toxin. Seven hundred and fourteen non-enterotoxigenic type A C. perfringen...

Cattle enterotoxaemia is one of numerous pathologies caused by Clostridium perfringens. These anaerobic Gram-positive bacteria are naturally present in the intestinal flora of mammals, but their uncontrolled multiplication under certain conditions results in the overproduction of toxins in the intestinal tract. Major clinical signs are induced by the systemic spread of these toxins in the blood...

The study was designed to determine the types of Clostridium perfringens and their toxins in sheep with suspected enterotoxemia in AlAhsa province, KSA. Out of 240 intestinal content samples collected from dead sheep with suspected enterotoxemia, 34 Clostridial strains were isolated. Diagnosis was based on classical diagnostic tests, enzyme-linked immunosorbent assay (ELISA) and multiplex polym...

BACKGROUND Enterotoxaemia produced by Clostridium perfringens A, C and D is an important cause of mortality in young llamas. There is no data on antibody responses following vaccination with epsilon toxin. METHODOLOGY Twenty-six L. glama crias were divided into four groups which were vaccinated with a commercial vaccine (Mancha Gangrena Enterotoxemia, Instituto Rosembusch Sociedad Anónima, Ar...

The enterotoxaemia syndrome in Belgian Blue calves is characterised by a high case fatality rate, sudden death, lesions of haemorrhagic enteritis of the small intestine and, quite often an absence of other clinical signs but its cause has not been yet identified. As a first step in this identification, the aerobic and anaerobic intestinal flora of a population of 78 calves, originating from far...