objective(s):to know whether scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (epcs) in hypertensive rats. materials and methods: the rats were divided in 5 groups: control (normotensive) group, desoxy cortico sterone (doca)-salt hypertensive group, and three doca-salt hypertensive groups. all 5...

Objective(s):To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. Materials and Methods: The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. All 5...

background: stem cell therapy for the treatment of vascular-related diseases through functional revascularization is one of the most important research areas in tissue engineering. the aim of this study was to investigate the in vitro differentiation of umbilical cl-msc into endothelial lineage cells. methods: in this study, isolated cells were characterized for expression of msc-specific marke...

introduction: endothelial progenitor colony forming unit-endothelial cells (cfu-ec) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. further studies revealed that they are monocytes regulating vasculogenesis. the main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. this study was unde...

background: radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (avm) may be used as markers for specific vascular targeting agents. in this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (pecam-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...

background: multiple sclerosis (ms) is an autoimmune disease of central nerves system, in which neurological disabilities occur in young adults. despite increasing number of studies on ms, some aspects of this disorder are still unclear. in the previous studies, it has been proven that there is direct relation between ms incidence and vitamin d deficiency. thereby, strong evidence in ms pathoge...

background: angiogenesis, the formation of new blood vessels from preexisting ones, is one of the most important physiological and pathological processes occur in the body. in the pathological conditions such as tumor growth, psoriasis, corneal neovascularization and rheumatoid arthritis, angiogenesis is crucially required for the devolopment of the disease. zataria multiflora as a member of la...

Human bone marrow derived mesenchymal stem cells (HBMSCs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. In this study, the differentiation of hBMSCs into endothelial like-cells was induced in presence of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1). The differentiated endothelial cells were exam...

background and purpose: during recent years, nitric oxide (no) has been considered as a molecule involved in migraine headaches. this free radical involves in initiation of migraine headaches via no/cgmp signaling pathway and vascular relaxation specially big intracranial arteries. therefore, we studied the effects of aqueous extract of origanum vulgare and melilotus officinalis prescribed in m...

introduction: endothelial cells are subjected to mechanical forces caused by pulsatile flow and pressure leading to hemodynamic shear stress and circumferential stress on endothelial layer. the study aimed at a quantitative evaluation of endothelial cell morphology by application of cyclic loading. endothelial cells respond to applied loads with adaptation and remodeling. such mechanisms are ma...