Objective The purpose of this study was to compare the effects of Glycyrrhiza glabra (Licorice), Cyclooxygenase-2 Inhibitor (Celecoxib®) and gonadotropin releasing hormone analog (Diphereline®) to a control group on endometrial implants in rats. MaterialsAndMethods Endometriosis was induced in rats by auto transplantation and after confirmation, the rats were divided into 4 groups that were tre...

background: endometriosis is defined as the growth of endometrial tissues in ectopic places outside the uterus. this disease has an important effect on the health and fertility of affected women. it’s etiology is not clearly known. for better understanding the pathophysiology of this disease, many researchers study on several aspects of the disease on animals. objective: in this experimental st...

OBJECTIVE To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and exami...

p50 is a member of the NF-kappaB family known to be involved in endometriosis. To gain insight into the roles of p50 in the development of endometriosis, we cross-transplanted endometrial fragments from p50 knockout mice to wild-type mice and vice versa, and also autotransplanted the fragments within the knockout and wild-type mice, inducing endometriosis. We then evaluated the size of the endo...

Several reports have documented adenocarcinoma arising from endometriotic implants within cesarean section (C-S) scars on the serosal surface of the uterus; however, endometrial cancer invading the C-S scar from the uterine cavity has not been described. We report a case of a grade 1 endometrioid adenocarcinoma 'drop' lesion invading a previous C-S scar with resultant cervical stromal invasion....

background: immune system disturbances have an important role in endometriosis which may lead to infertility. it seems that inflammatory cytokines specially tumor necrosis factor alpha (tnf-) which were produced by activated macrophages have an important role in pathology of endometriosis. based on this theory, anti tnf- drugs like pentoxifylline (px) are suggested as new drugs for endometrio...

OBJECTIVE Dienogest, a synthetic steroid with progestational activity, is used as a component of oral contraceptives and is currently being evaluated clinically for the treatment of endometriosis. The present study was conducted to confirm the effects of dienogest on experimental endometriosis in rats and to elucidate its mechanism of action. DESIGN Experimental endometriosis induced by autot...

decline suggests that the implanted oestradiol is eliminated from body tissues much more slowly than thought previously (figure). We emphasise that according to the recommendations in the Data Sheet Compendium our patients were not overdosed but were treated with a conventional regimen of 50 mg oestradiol implants reinserted roughly every six months. The mean oestradiol dose a year was 83 mg, w...

Endometriosis is defined as the presence of endometrial glands and stroma at extra-uterine sites; it is a common disease affecting women of reproductive age. Endometrial tissue can implant itself to various organs, including the gastrointestinal tract, and can cause significant gastrointestinal symptoms. These ectopic endometrial tissue implants are usually located in the pelvis but can be pres...

•Extra-uterine endometrial stromal sarcoma may arise in endometriosis.•Abdominal exploration for extra pelvic endometriosis is warranted.•Representative endometriotic implants should be resected and/or biopsied if clinically suspicious.