Endodontic management of the teeth with immature apices and necrotic pulps has always been challenging. Therefore fabrication of an artificial hard tissue barrier with a biomaterial has indicated as an alternative to more traditional apexification procedure. Successful endodontic treatment needs to prevent leakage of intracanal irritants into the peri radicular tissues. On the other hand, achie...

introduction: this in vitro study assessed and compared the cytotoxicity of mineral trioxide aggregate (mta), calcium-enriched mixture (cem) cement, biodentine (bd) and octacalcium phosphate (ocp) on stem cells of the human apical papilla (scap). methods and materials: scaps were isolated from two semi-impacted third molars. the cells were cultured in wells of an insert 24-well plate and were t...

Biomaterials such as membrane barriers and/or bone grafts are often used to enhance periapical new bone formation. A combination of apical surgery and these biomaterials is one of the latest treatment options for avoiding tooth extraction. In case of periapical lesions, guided tissue regeneration (GTR) is attempted to improve the self-regenerative healing process by excluding undesired prolifer...

background and aim: the main goal of endodontic treatments is eliminating the etiologic factors of pulpal and periapical diseases as well as maintaining this condition via providing a hermetic seal between periodontium and root canal system. if these were not possible through orthograde approach, periradicular surgery and root-end filling are indicated. review of literature: different materials...

introduction: flow rate (fr) and compressive strength (cs) are important properties of endodontic biomaterials that may be affected by various mixing methods. the aim of this experimental study was to evaluate the effect of different mixing methods on these properties of mineral trioxide aggregate (mta) and calcium-enriched mixture (cem) cement. materials and methods: hand, amalgamator and ultr...