background: x-ray repair cross-complementing group 1 (xrcc1) gene is a dna repair gene and its non-synonymous single nucleotide polymorphisms (snp) may influence dna repair capacity which has been considered as a modifying risk factor for cancer development. methods: a case-control study was conducted to investigate impact of three frequently studied polymorphisms (arg194trp, arg280his and arg3...

Endocrine-disrupting chemicals have the ability to interfere with and alter functions of hormone system, leading adverse effects on reproduction, growth development. Despite growing concerns over their now ubiquitous presence in environment, endocrine-related human health remain largely outside comparative toxicity characterization frameworks as applied for example life cycle impact assessments...

breast cancer affects iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in tehran. thisstudy aimed to compare the ahr levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. possible associations of ahr with lifestyle and reproductive risk factorsand ...

the prognosis of the neoplastic diseases depends not only on the biogenetic characteristics of cancer cells but also on the immunological response of patients, which may influence the biological features of cancer cells themselves as well as the angiogenic processes. moreover, the immune system in vivo is under a physiological psychoneuroendocrine (pne) regulation, mainly mediated by the brain ...

The pathogenesis of cancer in general is influenced by many factors, genetic and environmental. Epidemiological studies demonstrate familial aggregation of cancer in a significant proportion of cases. Many of these familial cancer syndromes contain endocrine hormone-related components. The etiology of endocrine-related cancers is complex, as is that of other cancers. Tumors of endocrine glands ...

background: polycystic ovary syndrome (pcos) is a heterogeneous complex genetic disorder characterized by hyperandrogenemia hyperinsulinemia insulin resistance and chronic anovulation. it is the most common endocrine disorder in women of reproductive age with an enigmatic pathophysiologic and molecular basis. obesity hyperandrogenism and infertility occur frequently in pcos which mostly have a ...