Enchondroma is a common, benign, hyaline-cartilage-forming tumor in the medulla of the bone, occurs at metaphysis or extended to diaphysis, and usually a single lesion. When there are multiple enchondromas, the term enchondromatosis is applied. There are 7 subtypes of enchondromatosis; the most common subtypes are Ollier disease and Maffucci syndrome which are distinguished by the presentation ...

BACKGROUND Enchondromatosis represent a heterogenous group of disorders. Spranger et al attempted a classification into 6 types: Ollier disease, Maffuci syndrome, metachondromatosis, spondyloenchondrodysplasia, enchondromatosis with irregular vertebral lesions, and generalized enchondromatosis. Halal and Azouz added 3 tentative categories to the 6 in the classification of Spranger et al. CASE...

IDH mutations are found in the majority of adult, diffuse, low-grade and anaplastic gliomas and are also frequently found in cartilaginous tumors. Ollier disease and Maffucci syndrome are two enchondromatosis syndromes characterized by the development of multiple benign cartilaginous tumors due to post-zygotic acquisition of IDH mutations. In addition to skeletal tumors, enchondromatosis patien...

We report a case of a 56-year old man with chronic pain in both knees for several years. This patient had already undergone surgery on his left knee in 2002 after an x-ray showed multiple lytic and well margined lesions in the distal femur and proximal tibia with ground-glass matrix, involving Hoffa's fat pad and the patellar ligament. Histology was consistent with an enchondroma. The most rece...

Enchondromas and conventional central chondrosarcomas are, respectively, benign and malignant hyaline cartilage-forming tumours that originate in the medulla of bone. In order to gain a better understanding of the molecular process underlying malignant transformation of enchondroma, and to investigate whether there is a biological difference between conventional central cartilaginous tumours an...

In contrast to solitary enchondroma,patients with multiple enchondromatosis of bone (Ollier's disease) get affected in childhood by bone swelling and growth retardation. In adults, the main problem is the risk of malign transformation up to 40%.Pain, increasing local tumor and thinning of the corticalis are the typical clinical and radiological signs of transformation to a low grade chondrosarc...

or Ollier's disease, is best called enchondromatosis, and was defined by Jaffe (1958) as the presence of either circumscribed foci or large masses of cartilage in the interior of bones. It may be confined to limb bones and often almost to one side of the body, as in the patients described by Ollier in 1900. The possibility of malignant change in a focus of enchondromatosis was considered to be ...