To investigate the reaction kinetics of the solid-state degradation process of enalapril maleate, a Fourier transform infrared microspectroscope equipped with thermal analyzer (thermal FT-IR microscopic system) was used. The isothermal stability study was conducted at 120-130 degrees C for 1-2 h and changes in the three-dimensional plots of the IR spectra of enalapril maleate with respect to he...

The chemical stability of enalapril maleate in tablet dosage forms consisting of different formulation excipients has been studied in this work. The influence of various parameters such as heat, moisture, light and the drug-matrix was investigated. The degradation of enalapril maleate has been followed by using an HPLC method, which was demonstrated to be specific, stability indicating, accurat...

The chemical stability of enalapril maleate in tablet dosage forms consisting of different formulation excipients has been studied in this work. The influence of various parameters such as heat, moisture, light and the drug-matrix was investigated. The degradation of enalapril maleate has been followed by using an HPLC method, which was demonstrated to be specific, stability indicating, accurat...

In this paper, the stability of enalapril maleate in oral formulations prepared from commercially available tablets was investigated. Extemporaneously compounded, 0.1 mg/mL and 1.0 mg/mL, oral suspensions of enalapril maleate in sugar-containing and sugar-free vehicles were stored in the absence of light at 4 degrees and 25 degrees C for 30 days. Enalapril maleate stability was quantified after...

Background Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrast-induced nephropathy (CIN). The aim of this study was to evaluate the protective effects of enalapril maleate and folic acid tablets on CIN in diabetic rats. Methods Thirty-two Sprague-Dawley rats were divided into four groups: CIN (C), CIN + enalapril maleate (CE), CIN ...

Enalapril is a highly specific, competitive inhibitor of angiotensin converting enzyme (ACE) belonging to the category of ACE inhibitors. The beneficial effects of ACE inhibitors appear to result primarily the suppression of the plasma renin-angiotensin-aldesteron system. The pharmacological actions of enalapril maleate are related to hypotension. Enalapril maleate is an ACE inhibitor that cont...

Pullulan, a water soluble, bioadhesive and biocompatible biopolymer is used as an efficient matrix for enalapril maleate film preparation. The obtained film contains as much as 67% of enalapril maleate, relative to the initial amount used for experiments. The drug content was evaluated by using 1 H-NMR and UV-vis spectroscopy. The pullulanenalaprilmaleate blends exhibit good physicochemical pro...

Franco R.P., Pereira G.T. & Camacho A.A. 2011. Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, chf functional class Ib. Pesquisa Veterinária Brasileira 31(9):791-797. Departamento de Clínica Médica e Cirúrgica de Pequenos Animais, Faculdade de Ciências Agrárias e Veterinária, Universidade do Estado de São Paulo, Via de Acesso Prof...

Three different sensitive and accurate spectroscopic procedures were developed for the determination of three angiotensin-converting enzyme inhibitors, namely, ramipril, enalapril maleate and fosinopril. The first two spectrophotometric (extractive and non-extractive) procedures were based on ternary complex formation with molybdenum(V) thiocyanate. The formed complex can be determined by extra...

Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesiv...