In open multi-agent systems trust models are an important tool for agents to achieve effective interactions. However, in these kinds of open systems, the agents do not necessarily use the same, or even similar, trust models, leading to semantic differences between trust evaluations in the different agents. Hence, to successfully use communicated trust evaluations, the agents need to align their...

Regulation of cell polarity and orientation is essential during symmetric and asymmetric cell division and cell differentiation, as well as in a large variety of cellular functions such as T cell interaction with their target cell, synaptic transmission, or cell migration (Krummel and Macara, 2006; Arimura and Kaibuchi, 2007; Etienne-Manneville, 2008). Directed as well as random cell migration ...

In open multi-agent systems trust models are an important tool for agents to achieve effective interactions. However, in these kinds of open systems, the agents do not necessarily use the same, or even similar, trust models, leading to semantic differences between trust evaluations in the different agents. Hence, to successfully use communicated trust evaluations, the agents need to align their...

To determine if the mammalian target of rapamycin (mTOR) inhibitor CCI-779 can sensitize head and neck squamous cell carcinoma (HNSCC) to radiotherapy (XRT) and compare the radiosensitizing effects to cisplatin with its known considerable toxicity. Radiosensitizing effects of CCI-779 were assayed on HNSCC cell lines in vitro. CCI-779 (5 mg/kg), cisplatin (1 mg/kg), and XRT (2 Gy) alone and in c...

Selective inhibition of repopulation of surviving tumor cells between courses of chemotherapy might improve the outcome of treatment. A potential target for inhibiting repopulation is the mammalian target of rapamycin pathway; PTEN-negative tumor cells are particularly sensitive to inhibition of this pathway. Here we study the rapamycin analogue CCI-779, alone or with chemotherapy, as an inhibi...

There are many causes for variation in the responses of the motor apparatus to neural commands. Fast-timescale disturbances occur when muscles fatigue. Slow-timescale disturbances occur when muscles are damaged or when limb dynamics change as a result of development. To maintain performance, motor commands need to adapt. Computing the best adaptation in response to any performance error results...

The mammalian target of rapamycin (mTOR) inhibitor CCI-779 (temsirolimus) is a recently Food and Drug Administration-approved anticancer drug with efficacy in certain solid tumors and hematologic malignancies. In cell culture studies, CCI-779 at the commonly used nanomolar concentrations generally confers a modest and selective antiproliferative activity. Here, we report that, at clinically rel...

Fumihiko Mahara1,2, Kazuaki Miyamoto1,2*, Hiromi Fujita2 and Teruo Mutsuda1 1Mahara Hospital, Aratono-cho Nobusato 6-1, Anan, 779-1510, Japan 2Mahara Institute of Medical Acarology, Aratano-cho Korekuni 56-3, Anan, 779-1510, Japan *Corresponding author: Kazuaki Miyamoto, Mahara Institute of Medical Acarology, Aratano-cho Korekuni 56-3, Anan, 779-1510, Japan, Fax/Tel: +81-884-36-3601; Email: kaz...