Phagocytosis, emperipolesis, and entosis are physiological and pathological phenomena characterized by the engulfment of one cell into another cell [1]. Emperipolesis is defined as active penetration of one cell by another, which remains intact [2]. Emperipolesis differs from phagocytosis in that an engulfed cell exists temporarily within another cell and with an intact normal structure, while ...

BACKGROUND Axillary lymph node metastases in women are most frequently associated with breast cancer. Few cases have been reported to be related to other primary tumors of the breast. Furthermore, emperipolesis, a phenomenon that occurs as a result of the phagocytosis of hematopoietic cells by neoplastic cells, is observed in few tumors. CASE A 72-year-old woman presenting endometrial and bre...

Natural killer (NK) cells can induce liver fibrosis remission by killing hepatic stellate cells (HSCs) and producing interferon (IFN)-γ in a mouse model; however, their anti-fibrotic immune-characteristics and regulatory mechanisms by HSCs remain to be determined, especially in livers from HBV-infected liver cirrhosis (LC) patients. We analyzed frequency, phenotype and anti-fibrotic function of...

In a previous communication (1), one of us described the propensity for emperipolesis exhibited by the cells of the mouse ascites lymphocytic tumor, Lymphoma No. 1 (L, 1). Emperipolesis, a term coined by Humble, Jayne, and Pulvertaft (2) to describe the "inside round about wandering" of lymphocytes within cells, has been observed by several investigators to occur under a variety of conditions (...

AIMS In this study, we aimed to evaluate the use of typical histological features of both the revised original (1999) and simplified (2008) criteria in the diagnosis of autoimmune hepatitis (AIH) in clinical practice. METHODS AND RESULTS We performed a detailed histopathological evaluation of the pretreatment biopsies of 63 AIH patients, and used biopsies of 62 untreated chronic viral hepatit...