UNLABELLED : Lu and Elston have recently proposed a procedure for developing optimal receiver operating characteristic curves that maximize the area under a receiver operating characteristic curve in the setting of a predictive genetic test. The method requires only summary data, not individual level genetic data. In an era of increased data sharing, we investigate the performance of this algor...

Two of the major approaches for linkage analysis with quantitative traits in humans include variance components and Haseman-Elston regression. Previously, these were viewed as quite separate methods. We describe a general model, fit by use of generalized estimating equations (GEE), for which the variance components and Haseman-Elston methods (including many of the extensions to the original Has...

The endemic Australian genus Apteropilo Lea is revised and Pylusopsis Elston syn. n. found to be synonymous with the former. Apteropilo is redefined herein to include two previously described species (A. pictipes Lea (= Pylusopsis peckorum Kolibáč syn. n.) and A. chrysocome (Elston) comb. n.), and four new species (A. raldae sp. n., A. humerofuscus sp. n., A. clarinotus sp. n. and A. volans sp....

To study the effect of individual genes by segregation or linkage analyses, the likelihood of the model needs to be evaluated. The likelihood can be computed efficiently using the Elston-Stewart algorithm. This algorithm involves summing over the unobserved genotypes in the pedigree, which is called peeling. An important aspect of this algorithm is to determine the order of peeling to maximize ...

Ever since Lotka (1926) published his inverse square law of scientific productivity, both the nature and origin of the phenomenon have been investigated in the literature. Although the specific parameters of those functions which indicate what proportion of scientists produces what bulk of scientific products vary with different indices (Davis, 1941; Leavens, 1953; Price, 1963; Britton, 1964; A...

Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included ...