BACKGROUND AND AIMS Endoscopic surveillance of Barrett's oesophagus currently relies on multiple random biopsies. This approach is time consuming, has a poor diagnostic yield, and significant interobserver variability. Elastic scattering spectroscopy is a real time in vivo optical technique which detects changes in the physical properties of cells. The aim of this study was to assess the potent...

We review the application of fluorescence spectroscopy and elastic-scattering spectroscopy, over the ultraviolet-to-visible wavelength range, to minimally invasive medical diagnostics. The promises and hopes, as well as the difficulties, of these developing techniques are discussed.

Introduction: There is a strong need for developing clinical technologies and instruments for prompt tissue assessment in a variety of oncological applications as smart methods. Elastic scattering spectroscopy (ESS) is a real-time, noninvasive, point-measurement, optical diagnostic technique for malignancy detection through changes at cellular and subcellular levels, especially important in ear...

Quantitative interpretation of electron spectroscopy is almost always dependent on the understanding of multiple scattering effects. Monte Carlo simulations are often used to model multiple scattering effects, as this method provides for a conceptually simple framework for incorporating both elastic and inelastic scattering processes. In this paper, we demonstrate that when small-angle deflecti...

To model elastic wave scattering from fatigue cracks in metals, studies were conducted of wave scattering from artificial cracks using ultrasonic spectroscopy. The cracks are of two dimensional planar strips oriented at various angles and embedded in diffusion bonded titanium alloy. The crack is assumed to behave as a Griffith crack and expressions (derived by Achenbach1) to describe diffracted...

In this chapter, coherent effects that accompany the propagation of laser radiation in tissues and the interaction of laser radiation with cell flows are considered. These effects include diffraction, formation of speckle structures, interference of speckle fields, scattering from moving particles, etc. Principles of quasi-elastic light scattering (QELS) spectroscopy, diffusion wave spectroscop...

Electron momentum spectroscopy (EMS) measures the spectral function of electrons in matter directly, provided that multiple scattering effects are negligibly small. Even for the thinnest films this is not the case and one has to correct for multiple scattering effects in order to retrieve the spectral function. Both elastic and inelastic scattering effects affect the measurement. Elastic scatte...

Tissue diagnostic techniques based on optical spectroscopy, in various incarnations, are approaching clinical reality for intraoperative guidance of surgical procedures. Examination of tissue properties by elastic light-scattering spectroscopy may constitute a preferable alternative to frozen-section pathology or touch imprint cytology for intraoperative assessment of resection margins during b...