Italiako Parlamentua, 1861 urtetik, ohizko erakunde legegilea edo gobernuaren kontrola egiten zuen baina horrez gain, Italiaren nazio eraikuntza gidatu zuen: Buruzagi ezberdinen nahiak bateratuz, trenbide sarea bultzatuz edo kode edo lege komunak burutuz. Parlamentuaren errolaren inguruan gaizki ulertzeak gertatu ohi dira eta horren inguruan gogoeta egiten da. Italian politika erlijio edo ideol...

The suprachiasmatic nucleus (SCN) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation of Per (period) and Cry (cryptochrome) genes by BMAL1-CLOCK complexes is suppressed by PER-CRY complexes. The molecular/structural basis of how circadian protein complexes function is poorly understood. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced muta...

There has been recent interest in techniques for diagnosing ejaculatory duct obstruction (EDO), especially when the partial form of the disease is suspected clinically. Currently, there is no gold standard technique for diagnosing EDO. Transrectal ultrasonography (TRUS), which is the technique used most widely, can overdiagnose EDO. As adjunctive diagnostic techniques, duct chro...

Single frequency acoustic scattering from an uncertain surface (with sinusoidal components) admits an efficient Fourier-polynomial chaos (FPC) expansion of the acoustic field. The expansion coefficients are computed nonintrusively, i.e., by functional sampling from existing acoustic models. The structure of the acoustic decomposition permits sparse selection of FPC orders within the framework o...

EDO-S101 is a first-in-class alkylating, histone deacetylase inhibitor (HDACi) fusion molecule with dual activity. It structurally combines the strong DNA damaging effect of bendamustine with a fully functional pan-HDAC inhibitor, vorinostat (Supplementary Figure S1) that is intended to simultaneously deliver DNAdamaging activity while inhibiting DNA repair activity, and is currently undergoing...

BACKGROUND Despite recent advances in the treatment of multiple myeloma (MM), the prognosis of most patients remains poor, and resistance to traditional and new drugs frequently occurs. EDO-S101 is a novel therapeutic agent conceived as the fusion of a histone deacetylase inhibitor radical to bendamustine, with the aim of potentiating its alkylating activity. METHODS The efficacy of EDO-S101 ...

We examine lifetime eating disorders (EDOs) and associations with post-traumatic stress disorder (PTSD) and sexual trauma during various stages of the life course (childhood, during military service, and lifetime) among women veterans. The sample included 1,004 women aged 20 to 52 years who had enrolled at 2 Midwestern Veterans Affairs Medical Centers or outlying clinics completed a retrospecti...

With the development of mechanized civilization, transportation of goods and people has become fast and convenient, at the expense of transportation noise which has become a serious problem. This paper aims at comparing the acoustical environment of a modern multi-million city (Tokyo) with the situation one to three centuries ago in the corresponding old city (Edo); also at that time one of the...

Eating disorders and obesity (EDO) are increasing among youth, having serious long-term physical and psychological consequences. The purpose of this study was to determine if significant differences exist in EDO risk factors following participation of 4-6th grade students in a school-based EDO prevention curriculum. This community-based research project assessed students at baseline and one wee...

Ejaculatory duct obstruction (EDO) underlies 1-5% of male infertility, although the diagnosis of EDO can be complex, treatment is well established and can be very effective. Part of reason that this condition probably is underdiagnosed, is because of its rarity, subtle presentation and the concomitantly low index of suspicion held by physicians. The causes of EDO are divided into congenital and...