myositis ossificans (mo) is a pathologic bone formation in soft tissue with unknown pathogenesis. in this article, we reported a case of long standing mo of right medial pterygoid muscle with severe limitation of mouth opening.

We report a family with dominantly inherited ectopic ossification. It is characterised by childhood onset of multifocal subcutaneous ossifications (primary osteoma cutis), which are of trivial clinical significance. One family member had extensive ectopic ossification involving one limb. We speculate that this may reflect somatic mutation having caused conversion to homozygosity.

Heterotopic ossification is characterised by the periarticular deposition of ectopic bone. It typically occurs after trauma, neurogenic injury, or congenital causes. Idiopathic heterotopic ossification has been rarely reported. A patient who developed idiopathic heterotopic ossification in the intensive care unit without any known predisposing conditions is presented.

Ectopic ossification occurs in a wide range of common and genetic diseases, but its molecular mechanisms and effective therapeutic targets remain to be clarified. The aim of the study is to investigate whether endoplasmic reticulum (ER) stress is involved in ectopic ossification and ER stress inhibitor tauroursodeoxycholic acid (TUDCA) has potential to treat the pathological conditions. In this...

BACKGROUND Ossification of the posterior longitudinal ligament (OPLL) of the spine is a common human myelopathy that leads to spinal cord compression. No disease-modifying drug for OPLL has been identified, whereas surgery and conservative management have been established. OBJECTIVES To evaluate the therapeutic potential of the H2 blocker famotidine for ectopic ossification in the cervical sp...

The syndrome of severe wasting, opisthotonus and paraplegia in flexion associated with considerable hydrocephalus is well known to those treating advanced cases of tuberculous meningitis. Once such a condition has developed, the outlook is generally poor. Many patients will die and the survivors will often be handicapped by a variety of physical and mental sequelae. The purpose of this paper is...