AN extensive outbreak of Echovirus type 4 took place during 1970-71 in Northern Ireland. Echovirus type 4 is not only a rare virus to isolate from patients but this was also the third major enterovirus outbreak in Northern Ireland during the past four years. The olther outbreaks were associated with Echovirus type 6 during 196;8 (Connolly and O'Neill, 1970) and Coxsackie A9 virus during 1970 (C...

Objectives Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30. Methods The cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known an...

Enteroviruses have been reported in encephalitis cases. However, clinical and epidemiological characteristics of enteroviruses in encephalitis are not fully established. We prospectively investigated 204 children with encephalitis over a period of 2 years (2009 to 2010) for enterovirus. Enterovirus was detected in 45 specimens (22.1%); of these, 40 were typed by seminested reverse transcription...

DURING 1974-75 there was an outbreak of meningitis associated with echovirus type 19 in Northern Ireland, which was the fourth major enterovirus outbreak during the past seven years. The other outbreaks were associated with echovirus type 6 during 1968 (Connolly and O'Neill, 1970), coxsackie A9 virus during 1970 (Connolly and O'Neill, 1971) and echovirus type 4 during 1970-71 (Connolly and O'Ne...

Infections by echovirus 13 are rare. In our country, it had not been previously reported any infection of this sort until 2000, when eleven echovirus 13 meningitis were observed in the Department of Pediatrics of the Hospital Fernando Fonseca. In England and Spain outbreaks of echovirus 13 meningitis during 2000 was also reported. Based on these facts the authors make an epidemiological analyse...

Berry PJ, Nagington J. Fatal infection with echovirus 11. Arch Dis Child 1982;57:22-9. 2 Krous HF, Dietzman D, Ray CG. Fatal infection with echovirus types 6 and 11 in early infancy. Am J Dis Child 1973;126:842-6. 3 Hughes JR, Wilfert CM, Moore M, et al. Echovirus 14 infection associated with fatal neonatal hepatic necrosis. Am J Dis Child 1972;123:61-7. 4 Philip AGS, Larson EJ. Overwhelming ne...

Echoviruses constitute one of the major groups of the genus Enterovirus and are associated with illnesses including aseptic meningitis, nonspecific rashes, encephalitis, and myositis (1). Echovirus 13 is an enterovirus that rarely has been detected in the United States, accounting for only 65 of approximately 45,000 enterovirus isolates reported to CDC during 1970-2000. No associated outbreaks ...

Echoviruses have been implicated in multiple human disease syndromes, including aseptic meningitis, paralysis, and heart disease, but no animal model is available for studying the pathogenesis of infection. Production of human integrin very late antigen 2, a receptor for echovirus type 1, in transgenic mice conferred susceptibility to viral infection. Intracerebral inoculation of newborn transg...

Soluble forms of decay-accelerating factor (DAF) (CD55), the receptor for echovirus 7, were synthesized in the yeast Pichia pastoris. Purified recombinant protein containing SCR domains 2, 3, and 4, but lacking the serine/threonine rich region, was shown to block infection of susceptible cells by echovirus 7. In contrast to the situation with poliovirus and its receptor, the neutralization of e...

background human enteroviruses are members of picornaviridae family; they are non-enveloped, icosahedral viruses with positive rna as genome. echovirus 30 is an important member of enteroviruses that is recognized in outbreaks of enterovirus meningitis. objectives the aim of this study was to determine relative frequency of echovirus 30 as an important agent of aseptic meningitis among children...