Abstract Multiple sclerosis (MS), an autoimmune disease of the central nervous system, is thought to be mediated by autoreactive CD4+ T cells producing IL-17A and IFNg. However, it unclear if these cytokines are essential for development, progression, or both. We have shown that neither IFNg nor IL-17A, alone, required development in experimental encephalomyelitis (EAE), a mouse model MS, but a...

Abstract Signal transducer and activator of transcription 4 (STAT4) is a critical regulator inflammation in autoimmunity by acting as messenger for pro-inflammatory cytokines including IL-12 IL-23. In experimental autoimmune encephalomyelitis (EAE), an animal model multiple sclerosis, germ-line deletion STAT4 mice results resistance to the development paralysis. Here, we examined cell-specific ...

In this paper, we show the existence of attached comultiplication structure on $\operatorname{Hom}_{eAe}(eA,D(Ae))$ if an $(eAe,A)$-bimodule $eA$ has double centraliser property over algebra $A$ with idempotent $e$. Then apply it gendo-Gorenstein algebras. As applications, give a sufficient and necessary condition for to be Gorenstein, bocs-theoretic characterisation property.

Event argument extraction (EAE) aims to identify the arguments of a given event, and classify roles that those play. Due high data demands training EAE models, zero-shot cross-lingual has attracted increasing attention, as it greatly reduces human annotation effort. Some prior works indicate generation-based methods have achieved promising performance for monolingual EAE. However, when applying...

Experimental autoimmune encephalomyelitis (EAE) is the most relevant animal model to study demyelinating diseases such as multiple sclerosis. EAE can be induced by active (active EAE) or passive (at-EAE) transfer of activated T cells in several species and strains of rodents. However, histological features of at-EAE model in C57BL/6 are poorly described. The aim of this study was to characteriz...

All over the world, Escherichia coli (STEC), which produces Shiga toxin, is recognized as an important zoonotic pathogen. Ruminants, particularly cattle, are their main reservoirs, but role of small ruminants in epidemiology human infections has not been extensively evaluated many countries. In this study, it was aimed to determine toxin subtypes Stx1, Stx2, eae and ehxa genes producing isolate...

Multiple sclerosis (MS) is a common central nervous system disease associated with progressive physical impairment. To study the mechanisms of the disease, we used experimental autoimmune encephalomyelitis (EAE), an animal model of MS. EAE is induced by myelin oligodendrocyte glycoprotein35-55 peptide, and the severity of paralysis in the disease is generally measured using the EAE score. Here,...

Background : Exercise training induces beneficial effects on neurodegenerative diseases, and specifically multiple sclerosis (MS) it’s model experimental autoimmune encephalomyelitis (EAE). However, it is unclear whether exercise exerts direct protective the central nervous system (CNS), nor are mechanisms of neuroprotection fully understood. In this study, we investigated neuroprotective high-...