BACKGROUND/AIMS H. pylori CagL amino acid polymorphisms such as Y58/E59 can increase integrin α5β1 expression and gastric cancer risk. Hypochlorhydria during chronic H. pylori infection promotes gastric carcinogenesis. The study test whether CagL-Y58/E59 isolates may regulate integrin α5β1 to translocate CagA via the type IV secretory system even under adverse pH conditions, and whether the int...

The type IV secretion system (T4SS) is a major virulence determinant of the gastric pathogen Helicobacter pylori. The CagL protein is a specialized adhesin of the corresponding T4SS pilus, which establishes initial contact with the integrin β1 receptor on host target cells. Recent studies proposed that Y58 and E59 amino acid polymorphisms in CagL increase the virulence of H. pylori strains by e...

Enterovirus 71 (EV71) and coxsackievirus (CVA) are the most common causative factors for hand, foot, and mouth disease (HFMD) and neurological disorders in children. Lack of a reliable animal model is an issue in investigating EV71-induced disease manifestation in humans, and the current clinical therapies are symptomatic. We generated a novel EV71-infectious model with hSCARB2-transgenic mice ...

A stumbling point for many learning to fly fish is being able to fly cast well enough to ‘present’ a fly to a feeding fish. Even among more skilled fly fishers, learning to fly cast better is often a bottleneck towards advancement in the sport. Fly casting instruction today relies on the visual inspection of the fly casting stroke and the resulting ‘loop’ of fly line. These qualitative visual c...

s / Brain Stimulation 10 (2017) e46ee83 e59 features such as irritability and anxiousness as part of general participation in the study. Future studies will utilize neuroimaging to confirm targeted engagement of the DLFPC in order to enhance changes in mood with tDCS in MS participants. We will also characterize changes in mood in participants with clinically significant mood problems at baseli...

Traditional models of bank runs do not allow for herding e¤ects, because in these models withdrawal decisions are assumed to be made simultaneously. I extend the banking model to allow a depositor to choose his withdrawal time. When he withdraws depends on his consumption type (patient or impatient), his private, noisy signal about the quality of the bank’s portfolio, and the withdrawal histori...

During prenatal development of the cat's retinogeniculate projection, inputs from the ganglion cell axons of the two eyes are initially intermixed with each other within the lateral geniculate nucleus (LGN). As development proceeds, the inputs sort out to give rise to the eye-specific layers characteristic of the adult. During this sorting out process, individual axons undergo a stereotyped seq...

The title compound, [Co(C(2)N(3))(2)(C(3)H(7)NO)(2)](n), is a triclinic polymorph of the previously reported monoclinic structure [Tong et al. (2003 ▶). Acta Cryst. E59, m405-m407]. The Co(II) ion lies on an inversion centre and adopts an almost regular octa-hedral N(4)O(2) coordination geometry. Adjacent Co(II) atoms are connected by two bridging dicyanamide ligands, resulting in the formation...

In order to understand why there is a continuous increase in euro banknote circulation even though the use of cash for transactions decreasing area – phenomenon known as paradox banknotes members Overseas workstream Eurosystem Research Network on Cash (EURECA) have conducted study foreign demand banknotes. The results this are based desk research using data collected and from other organisation...