نتایج جستجو برای: e4

تعداد نتایج: 3623  

Journal: :The British journal of nutrition 2013
R Chouinard-Watkins C Rioux-Perreault M Fortier J Tremblay-Mercier Y Zhang P Lawrence M C Vohl P Perron D Lorrain J T Brenna S C Cunnane M Plourde

Carrying the apoE ε4 allele (E4+ ) is the most important genetic risk for Alzheimer’s disease. Unlike non-carriers (E4- ), E4+ seem not to be protected against Alzheimer's disease when consuming fish. We hypothesised that this may be linked to a disturbance in n-3 DHA metabolism in E4+. The aim of the present study was to evaluate [13C]DHA metabolism over 28 d in E4+ v. E4-. A total of forty pa...

Journal: :Journal of virology 2001
D L Thomas J Schaack H Vogel R Javier

Among oncogenic adenoviruses, human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumors in rats and in not requiring viral E1 region transforming genes for tumorigenicity. Instead, studies with hybrid viruses generated between Ad9 and the closely related nontumorigenic virus Ad26 have roughly localized an Ad9 oncogenic determinant(s) to a segment of the ...

2014
Simon Evans Nicholas G. Dowell Naji Tabet Paul S. Tofts Sarah L. King Jennifer M. Rusted

The apolipoprotein E (APOE) e4 allele is strongly associated with increased risk of cognitive impairments in older adulthood. There is also a possible link to enhanced cognitive performance in younger adults, and the APOE e4 allele may constitute an example of antagonistic pleiotropy. The aim of this work was to investigate the cognitive and neural (functional) effects of the APOE e4 allele dur...

Journal: :Journal of virology 2006
Gillian L Knight Andrew S Turnell Sally Roberts

The infectious cycle of human papillomavirus type 1 (HPV1) is accompanied by abundant expression of the full-length E1;E4 protein (17-kDa) and smaller E4 polypeptides (16-, 11-, and 10-kDa) that arise by sequential loss of N-terminal E1;E4 sequences. HPV1 E4 inhibits G(2)-to-M transition of the cell cycle. Here, we show that HPV1 E4 proteins mediate inhibition of cell division by more than one ...

2015
Elizabeth I. Vink Yueting Zheng Rukhsana Yeasmin Thomas Stamminger Laurie T. Krug Patrick Hearing Joanna Parish

The Adenovirus E4-ORF3 protein facilitates virus replication through the relocalization of cellular proteins into nuclear inclusions termed tracks. This sequestration event disrupts antiviral properties associated with target proteins. Relocalization of Mre11-Rad50-Nbs1 proteins prevents the DNA damage response from inhibiting Ad replication. Relocalization of PML and Daxx impedes the interfero...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Sook-Young Sohn Patrick Hearing

The adenovirus (Ad) early region 4 (E4)-ORF3 protein regulates diverse cellular processes to optimize the host environment for the establishment of Ad replication. E4-ORF3 self-assembles into multimers to form a nuclear scaffold in infected cells and creates distinct binding interfaces for different cellular target proteins. Previous studies have shown that the Ad5 E4-ORF3 protein induces sumoy...

Journal: :Thermal Science 2022

In the present study, we deal with canal hypersurfaces according to extended Darboux frame field of second kind in Euclidean 4-space (E4) and this context, firstly obtain Gaussian, mean principal curvatures hypersurface give some results for flatness minimality these E4. Also, Weingarten E4 finally, construct an example.

2014
Maria Silvia Giretti Maria Magdalena Montt Guevara Elena Cecchi Paolo Mannella Giulia Palla Stefania Spina Guja Bernacchi Silvia Di Bello Andrea Riccardo Genazzani Alessandro D. Genazzani Tommaso Simoncini

Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or the central nervous system, while antagonizing the actions of estradiol in th...

Akbari MT Asgari N Babamohammadi GH Zare Sh

Background: The role of apolipoprotien E polymorphisms do not diagnostic correctly in recurrent pregnancy loss etiology but Apo E has been shown to play an important role in lipid metabolism in pregnancy. We evaluated these polymorphisms in Iranian women with unexplained recurrent pregnancy loss. Materials and Methods: 5 ml Blood were sampling from 81 women with a history of two or more consecu...

2013

Definition 4. We label lines 4-8 of the 4PPC algorithm as the reinstate procedure. This procedure reinstates a timepoint vk by, for every pair of previously-reinstated, neighboring timepoints vi and vj, tightening edge eki and edge ejk with respect to eij. Lemma 1. Let o and o′ be two distinct total orderings of the vertices, V for some graph G = 〈V,E〉. If o′ is consistent with the precedence r...

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