نتایج جستجو برای: e26

تعداد نتایج: 326  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
Y Wu P Duesberg

The oncogene hypothesis postulates that mutated cellular genes, termed proto-onc genes, function as cancer genes because they are related to retroviral onc genes. However, in contrast to retroviral onc genes, mutated proto-onc genes from cancers are not sufficient for carcinogenesis. Therefore, it has been proposed that mutated proto-onc genes depend on other proto-onc genes for carcinogenesis....

Journal: :Physica Medica 2021

PurposeTo investigate the effect of data quality and quantity on performance deep learning (DL) models, for dose prediction intensity-modulated radiotherapy (IMRT) esophageal cancer.Material methodsTwo databases were used: a variable database (VarDB) with 56 clinical cases extracted retrospectively, including user-dependent variability in delineation planning, different machines beam configurat...

Journal: :Virology 2007
Jared K Burks Max D Summers Sharon C Braunagel

Autographa californica nucleopolyhedrovirus Ac16 is 1 of 17 genes conserved within Type 1 nucleopolyhedroviruses. This report demonstrates that multiple isoforms of the protein encoded by Ac16, BV/ODV-E26 (E26), are present in the infected cell. One form of E26 associates with viral DNA or DNA-binding proteins, while a second form associates with intracellular membranes and this is likely due t...

2003
PETER H. DUESBERG

Replication-defective acute leukemia viruses E26 and myeloblastosis virus (AMV) cause distinct leukemias although they belong to the same subgroup of oncogenic avian tumor viruses based on shared transformation-specific (onc) RNA sequences. E26 causes predominantly erythroblastosis in chicken and in quail, whereas AMV induces a myeloid leukemia. However, upon cultivation in vitro for >1 month, ...

Journal: :Blood 2003
Kelly M McNagny Thomas Graf

Acute chicken leukemia retroviruses, because of their capacity to readily transform hematopoietic cells in vitro, are ideal models to study the mechanisms governing the cell-type specificity of oncoproteins. Here we analyzed the transformation specificity of 2 acute chicken leukemia retroviruses, the Myb-Ets- encoding E26 virus and the ErbA/ErbB-encoding avian erythroblastosis virus (AEV). Whil...

2003
Kelly M. McNagny Thomas Graf

Acute chicken leukemia retroviruses, because of their capacity to readily transform hematopoietic cells in vitro, are ideal models to study the mechanisms governing the cell-type specificity of oncoproteins. Here we analyzed the transformation specificity of 2 acute chicken leukemia retroviruses, the Myb-Ets– encoding E26 virus and the ErbA/ErbBencoding avian erythroblastosis virus (AEV). While...

Journal: :Human molecular genetics 2004
Kun Tang Li Peng Wong Edmund J D Lee Samuel S Chong Caroline G L Lee

The MDR1 multidrug transporter regulates the traffic of drugs, peptides and xenobiotics into the body as well as sensitive tissues like the brain, germ cells and the developing fetus. Hence, it may influence an individual's response to drugs as well as his/her susceptibility to complex diseases in which environmental factors, especially xenobiotics, play a role. Polymorphisms within this gene, ...

Journal: :Geophysical Research Letters 2021

The Galileo spacecraft passed close to Europa on 11 encounters, two of which (E12 and E26) came within 400 km the surface. In E12 data, there are perturbations in field plasma data consistent with effects a nearby plume (Jia et al., 2018). Huybrighs al. (2020, https://doi.org/10.1029/2020GL087806) report depletions proton flux one channel Energetic Particle Detector (EPD) as E26. They trace par...

Journal: :Journal of virology 1984
K H Klempnauer J M Bishop

The genome of avian leukemia virus E26 shares homology with v-myb, the oncogene of avian myeloblastosis virus, and encodes a protein with an Mr of 135,000. Analyses of tryptic oligopeptides show that this protein is related to the proteins encoded by gag (Pr76gag) as well as v-myb (p45v-myb[AMV] ) and c-myb (p75c-myb). We found no evidence for the existence of additional myb-related proteins or...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2017
Yang Li Yanxia Liu Xiaoxiang Tian Yan Zhang Haixu Song Meili Liu Xiaolin Zhang Haiwei Liu Jian Zhang Quanyu Zhang Dan Liu Chengfei Peng Chenghui Yan Yaling Han

OBJECTIVE Cellular repressor of E1A-stimulated genes (CREG) is a lysosomal glycoprotein implicated in maintaining vascular homeostasis. Here, we have hypothesized that CREG is a critical target of intervention for the prevention of hypertensive vascular remodeling. APPROACH AND RESULTS CREG gene expression was significantly decreased accompanied by an upregulated expression of angiotensin II ...

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