نتایج جستجو برای: dxr

تعداد نتایج: 310  

Journal: :Cancer research 1984
Q G van Hoesel P A Steerenberg D J Crommelin A van Dijk W van Oort S Klein J M Douze D J de Wildt F C Hillen

LOU M/Wsl rats inoculated s.c. with 10(4) immunoglobulin immunocytoma cells have a palpable tumor at Day 17. Doxorubicin (DXR) has been entrapped in negatively charged liposomes (lip- DXR) composed of egg phosphatidylcholine, cholesterol, and phosphatidylserine and in positively charged liposomes (lip+ DXR) composed of phosphatidylcholine, cholesterol, and stearylamine. DXR, lip- DXR, and lip+ ...

Journal: :Talanta 2009
Sameh Ahmed Naoya Kishikawa Kaname Ohyama Mitsuhiro Wada Kenichiro Nakashima Naotaka Kuroda

A highly sensitive and selective high-performance liquid chromatography (HPLC) method was developed for the determination of doxorubicin (DXR) and its metabolite doxorubicinol (DXR-ol) in rat plasma. The method was based on photosensitization reaction followed by peroxyoxalate chemiluminescence detection (PO-CL). DXR and DXR-ol that were fluorescent quinones, served as a photosensitizer in the ...

Journal: :Cancer research 1993
K Ohkawa T Hatano K Yamada K Joh K Takada Y Tsukada M Matsuda

A bovine serum albumin-conjugated doxorubicin via the glutaraldehyde bridge (BSA-DXR conjugate) showed potent dose-dependent inhibition of cell growth against daunorubicin-resistant AH66 (AH66DR) cells as well as parental AH66 (AH66P) cells in vitro as compared to treatment with DXR or BSA-glutaraldehyde conjugate without DXR (BSA-GA). In the culture of AH66DR with BSA-DXR conjugate, drug accum...

Journal: :International journal of pharmaceutics 2008
Jun-ichi Yokoe Shiho Sakuragi Kayoko Yamamoto Takuya Teragaki Ken-ichi Ogawara Kazutaka Higaki Naohisa Katayama Toshiya Kai Makoto Sato Toshikiro Kimura

To evaluate the effect of coupling of recombinant human serum albumin (rHSA) onto the surface of poly(ethylene glycol)-modified liposome (PEG liposome) on the in vivo disposition characteristics of liposomal doxorubicin (DXR), the pharmacokinetics and tissue distribution of DXR were evaluated after intravenous administration of rHSA-modified PEG (rHSA/PEG) liposomal DXR into tumor-bearing rats....

Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major (P. major) extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR, and Ext1200+DXR. Duration of the...

2013
Alvilde Dhainaut Mari Hoff Unni Syversen Glenn Haugeberg

OBJECTIVE Reduced bone mineral density (BMD), assessed by Dual Energy X-ray absorptiometry (DXA), is a well-known risk factor for fragility fracture. A large proportion of patients with fracture have only slightly reduced BMD. Assessment of other bone structure features than BMD may improve identification of individuals at increased fracture risk. Digital X-ray radiogrammetry (DXR), which is a ...

Journal: :Cancer research 2003
Fabio Pastorino Chiara Brignole Danilo Marimpietri Puja Sapra Elaine H Moase Theresa M Allen Mirco Ponzoni

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Intensive therapeutic intervention does not prolong the overall disease-free survival rate for this tumor. NB tumor, but not normal tissues, overexpress the disialoganglioside (GD(2)) at the cell surface. Anti-GD(2) whole antibodies (aGD(2)) or their corresponding Fab' fragments were covalently coupled to Stealth immuno...

Journal: :Oncology reports 2007
Takahiko Oyama Masafumi Kawamura Tomohiro Abiko Yotaro Izumi Masazumi Watanabe Eiji Kumazawa Hiroshi Kuga Yoshinobu Shiose Koichi Kobayashi

A novel drug delivery system (DDS) compound was formed by binding doxorubicin hydrochloride (DXR) to the macromolecular carrier carboxymethyldextran polyalcohol (CM-Dex-PA) via the peptidyl spacer (GGFG: Gly-Gly-Phe-Gly). Its use in a murine tumor model confirmed that the DDS (CM-Dex-PA-GGFG-DXR) was retained in the blood and distributed in tumor tissue. The combined use of hyperthermia (HT: 41...

ژورنال: :پاتوبیولوژی مقایسه ای 2015
مژده موسوی پژمان مرتضوی ناهید اطیابی ملیحه عباسعلی پورکبیره

دوکسوروبیسین یکی از شناخته ترین داروهای ضد سرطان میباشد. چای سبز نیزخواص آنتی اکسیدانی فراوانی دارد. در این مطالعه، اثر استفاده طولانی مدت چایسبز بر ضایعات ایجاد شده توسط دوکسوروبیسین در مغز استخوان موش صحراییمورد بررسی قرار گرفت.30 سرموش صحرایی نر بالغ نژاد ویستار بصورت تصادفی در 6 گروه مساوی، تقسیم شدند. شاهد، lgt استفاده از عصاره 3% چای سبز به مدت 60 روز)، shgt (استفاده از عصاره 3% چای سبز ب...

Journal: :Cancer research 2011
Jie Huang Jianqi Yang Biswanath Maity Daisuke Mayuzumi Rory A Fisher

Doxorubicin (DXR), among the most widely used cancer chemotherapy agents, promotes cancer cell death via activation of ataxia telangiectasia mutated (ATM) and the resultant upregulation of tumor suppressor p53. The exact mechanism by which DXR activates ATM is not fully understood. Here, we discovered a novel role for regulator of G protein signaling 6 (RGS6) in mediating activation of ATM and ...

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