BACKGROUND The role of diabetes mellitus, liver disease, and epilepsy as risk factors for Dupuytren disease remains unclear. In this systematic review and meta-analysis, the strength and consistency of these associations were examined. METHODS The MEDLINE, EMBASE, and Web of Science databases were searched for articles reporting an association between Dupuytren disease and diabetes mellitus, ...

Dupuytren disease is a fibrotic disorder characterized by contraction of myofibroblastrich cords and nodules in the hands. The Hippo member Yes-associated protein 1 (YAP) is activated by tissue stiffness and the pro-fibrotic transforming growth factor-β1, but its role in cell fibrogenesis is yet unclear. We hypothesized that YAP regulates the differentiation of dermal fibroblasts into highly co...

Cerveau et de L’Œil, Groupe Hospitalier Lariboisière – Fernand Widal, Paris, France ; 5 INSERM UMR_S 740, Université Paris Diderot, Sorbonne Paris Cité, Paris 6 Service de Neurologie, CHU de Limoges, Hôpital Dupuytren, Limoges, France; 7 Service de Cardiologie, CHU de Limoges, Hôpital Dupuytren, Limoges, France; 8 Unité Mixte de Recherche en Santé (UMR_S956), Université Pierre & Marie Curie (UP...

Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite...

Dupuytren disease is a fibrotic disorder characterized by contraction of myofibroblast-rich cords and nodules in the hands. The Hippo member Yes-associated protein 1 (YAP1) is activated by tissue stiffness and the profibrotic transforming growth factor-β1, but its role in cell fibrogenesis is yet unclear. We hypothesized that YAP1 regulates the differentiation of dermal fibroblasts into highly ...

Dupuytren´s disease, a fibromatosis of the connective tissue in the palm, is a common complex disease with a strong genetic component. Up to date nine genetic loci have been found to be associated with the disease. Six of these loci contain genes that code for Wnt signalling proteins. In spite of this striking first insight into the genetic factors in Dupuytren´s disease, much of the inherited ...

BACKGROUND Multidisciplinary treatment guidelines for Dupuytren disease can aid in optimizing the quality of care for patients with this disorder. Therefore, this study aimed to achieve consensus on a multidisciplinary treatment guideline for Dupuytren disease. METHODS A European Delphi consensus strategy was initiated. A systematic review reporting on the effectiveness of interventions was c...

394 Dupuytren disease is a benign fibroproliferative disease of some of the palmar fascias of the hand. This disease causes the formation of nodules that can eventually progress into cords, giving rise to flexion contractures of the affected fingers. Etiologic risk factors previously described include smoking, alcohol consumption, manual work, hand trauma, diabetes mellitus, and epilepsy.1–4 Ho...

M. H. SEEGENSCHMIEDT, MD Professor, Dept. of Radiation Oncology and Therapeutic Radiology, Alfried Krupp Hospital, Alfried Krupp Strafle 21, 45117 Essen, Germany 9.5.3 Radiotherapeutic Management 174 9.5.3.1 Radiobiological Rationale 175 9.5.3.2 Radiotherapy Technique 176 9.5.3.3 Results of Radiotherapy in Morbus Dupuytren I77 9.5.3.4 Possible Risks of Radiotherapy 178 9.5.3.5 Own Clinical Resu...

The ratio of the lengths of the second and fourth digits (2D:4D) has been described as reflecting endogenous prenatal androgen exposure. In general, 2D:4D is lower in men than in women and has potential as a biomarker or predictor for various diseases, athletic ability, and academic performance. Dupuytren disease has digital flexion contractures and is known to predominate in men, but the patho...