in this paper using strongly duplexes we introduce a new class of (semi)hypergroups. the associated (semi)hypergroup from a strongly duplex is called duplex (semi)hypergroup. two computer programs written in matlab show that the two groups $z_{2n}$ and $z_{n}times z_{2}$ produce a strongly duplex and its associated hypergroup is a complementary feasible hypergroup.

BACKGROUND RNAi is a prominent tool for the identification of novel regulatory elements within complex cellular pathways. In invertebrates, RNAi is a relatively straightforward process, where large double-stranded RNA molecules initiate sequence-specific transcript destruction in target cells. In contrast, RNAi in mammalian cell culture assays requires the delivery of short interfering RNA dupl...

Natural base pairs stabilize nucleic acid duplexes via hydrogen bonding and stacking interactions, efforts have been made to identify artificial that through different interactions. Herein, we describe our attempts prepare pseudo exhibit high stability orthogonality. Pairs of azobenzene derivatives showed unexpectedly orthogonality due intermolecular cationic molecules even higher than natural ...

This study investigated the influence of the nature of oligonucleotides on the abilities to form antiparallel and parallel duplexes. Base pairing of homopurine DNA, 2'-O-MeRNA and RNA oligonucleotides with respective homopyrimidine DNA, 2'-O-MeRNA and RNA as well as chimeric oligonucleotides containing LNA resulted in the formation of 18 various duplexes. UV melting, circular dichroism and fluo...

MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute (Ago) proteins, we determine that miRNAs are expressed in a 13-fold excess relative to Agos in HeLa cells and that miRNAs are bound to mRNAs in a sevenfold excess relative to Agos, implyi...

Small interfering RNA (siRNA) duplexes are short (usually 21 to 24 bp) double-stranded RNAs (dsRNAs) with several overhanging nucleotides at both 5'- and 3'-ends. It has been found that siRNA duplexes bind the RNA-induced silencing complex (RISC) and cleave the sense strands with endonucleases. In this study, for the first time, we detected siRNA duplexes induced by plant viruses on a large sca...

Oligomers equipped with a sequence of phenol and pyridine N-oxide groups form duplexes via H-bonding interactions between these recognition units. Reductive amination chemistry was used to synthesize all possible 3-mer sequences: AAA, AAD, ADA, DAA, ADD, DAD, DDA, and DDD. Pairwise interactions between the oligomers were investigated using NMR titration and dilution experiments in toluene. The ...

In this paper using strongly duplexes we introduce a new class of (semi)hypergroups. The associated (semi)hypergroup from a strongly duplex is called duplex (semi)hypergroup. Two computer programs written in MATLAB show that the two groups $Z_{2n}$ and $Z_{n}times Z_{2}$ produce a strongly duplex and its associated hypergroup is a complementary feasible hypergroup.

Cationic porphyrin-anthraquinone hybrids bearing peripheral substituents, either pyridine, imidazole, or pyrazole rings have been investigated for their binding mode to DNA duplexes. The four kinds of DNA duplexes were used, which represent intercalation and groove binding modes. AutoDock 4.2 was used to dock nine hybrid compounds to four DNA duplexes, while monitoring of conformational changes...