Objective(s): Response surface methodology (RSM) by central composite design (CCD) was applied to statistically optimize the preparation of Rutin-Quercetin (Ru-Qr) dual drug loaded human hair keratin nanoparticles as well as evaluate the characteristics. Materials and Methods: The effects of three independent parameters, namely, temperature (X1:10-40 C), surfactant (X2: SDS (1), SLS (2), Tween-...

objective(s): response surface methodology (rsm) by central composite design (ccd) was applied to statistically optimize the preparation of rutin-quercetin (ru-qr) dual drug loaded human hair keratin nanoparticles as well as evaluate the characteristics. materials and methods: the effects of three independent parameters, namely, temperature (x1:10-40 c), surfactant (x2: sds (1), sls (2), tween-...

Nano-structured surface and its ability to dual release of osteogenic and anti-inflammatory agents have a positive effect on the success of using titanium in orthopedic applications. For this purpose, TiO2 nanotubes (TNTs) were created via anodization method on Ti sheets and loaded by β-glycerophosphate (GP) and dexamethasone (DEX) as osteogenic and anti-inflammatory agents, respecti...

Rotator cuff injury causes pain in the shoulder and is a challenge to be repaired even after surgical reconstruction. Here, we developed dual-factor releasing hydrogel based on sulfhydrylated chitosan deliver KGN FGF-2 injured area enable fast healing of tendon–bone interface, which essential for repair rotator injury. We found that two factors could easily loaded into hydrogel, turn continuous...

Binding effect refers to the perceptual attraction between an action and an outcome leading to a subjective compression of time. Most studies investigating binding effects exclusively employ the "pressing" action without exploring other types of actions. The present study addresses this issue by introducing another action, releasing action or the voluntary lifting of the finger/wrist, to invest...

OBJECTIVE Vasculogenic progenitor cell therapy for ischemic diseases bears great potential but still requires further optimization for justifying its clinical application. Here, we investigated the effects of in vivo tissue engineering by combining vasculogenic progenitors with injectable scaffolds releasing controlled amounts of proangiogenic growth factors. METHODS AND RESULTS We produced b...

The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote ang...